Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis
Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis
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DOI：
10.1016/j.jad.2011.02.001
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发表时间：
2011-07-01
影响因子：
6.6
通讯作者：
Cuccaro, Michael L.
中科院分区：
文献类型：
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作者：
Carver, Charles S.;Johnson, Sheri L.;Cuccaro, Michael L.
5-羟色胺转运体多态性（5-HTTLPR）和脑源性神经营养因子（BDNF）val 66 met多态性都与抑郁症症状和抑郁症诊断（MDD）有关，并且与逆境相互作用;也没有发现影响。我们在一个大学样本中重新检查了这两种相互作用对终身MDD的影响。通过DSM-IV的结构化临床访谈对133名大学生进行了终生MOD的诊断;从血液中检测了5-HTTLPR和BDNF的基因型，并收集了关于儿童期逆境（风险）的自我报告。5-HTTLPR与风险相互作用，使得风险预测II型携带者中MDD的可能性较小，并且倾向于预测S型携带者中MDD的可能性较大。BDNF与Risk相互作用，使得Risk预测met携带者中MDD的可能性更大，并且不影响瓦尔/瓦尔携带者。这两种相互作用是加性的：在组合模型中两者都是显著的。(C)出版社：Elsevier B. V.
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. We reexamined both interactions for lifetime MDD in a college sample. Lifetime MOD was diagnosed by Structured Clinical Interview for DSM-IV in 133 undergraduates; genotypes for 5-HTTLPR and BDNF were assayed from blood, and self-reports were collected concerning childhood adversity (Risk). 5-HTTLPR interacted with Risk such that Risk predicted less likelihood of MDD among II carriers and tended to predict greater likelihood of MDD among s carriers. BDNF interacted with Risk such that Risk predicted greater likelihood of MDD among met carriers and did not influence val/val carriers. These two interactions were additive: both were significant in a combined model. (C) 2011 Published by Elsevier B.V.