Meta-Analysis of the Diagnostic Efficiency of THSD7A-AB for the Diagnosis of Idiopathic Membranous Nephropathy.
Meta-Analysis of the Diagnostic Efficiency of THSD7A-AB for the Diagnosis of Idiopathic Membranous Nephropathy.
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DOI：
10.1002/gch2.201900099
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Xu D
中科院分区：
文献类型：
--
作者：
Liu Y;Zheng S;Ma C;Lian Y;Zheng X;Guan P;Wang B;Gong X;Gao F;Liang L;Xu D
Thrombospondin type I domain-containing 7A（THSD 7A）是成人特发性膜性肾病（IMN）的特异性自身抗原，其循环抗体（THSD 7A-AB）是诊断IMN的有希望的生物标志物。本Meta分析的目的是研究THSD 7A-AB对IMN的诊断效率。经过严格的数据提取，质量评估和数据分析，10篇文章（4545例患者）。对于IMN，总体灵敏度为4%（2-7%），特异性为99%（98-100%）。汇总阳性似然比（PLR）和阴性似然比（NLR）分别为5.40（2.40-11.90）和0.97（0.95-0.99）。诊断优势比（DOR）为6.00（2.00-12.00）。汇总受试者工作特征曲线下面积（AUC）为0.78（0.74-0.81）。对于M型磷脂酶A2受体（PLA 2 R）阴性IMN，总体灵敏度为8%（6-10%），特异性为100%（99-100%）。总PLR和NLR分别为15.80（5.70-44.00）和0.93（0.91-0.95）。DOR为17.00（6.00-48.00）。AUC为0.99（0.98-1.00）。THSD 7A-AB在PLA 2 R阴性患者中的诊断价值高于IMN患者。这些结果表明，THSD 7A-AB可能用作PLA 2 R阴性IMN的辅助非侵入性诊断方法。本Meta分析首次系统评估了THSD 7A-AB检测在成人特发性膜性肾病（IMN）患者中的诊断效率。研究发现，含血小板反应蛋白I型结构域7A（THSD 7A）-AB对M型磷脂酶A2受体（PLA 2 R）阴性患者的诊断价值高于IMN患者。THSD 7A-AB检测可作为PLA 2 R阴性IMN的辅助非侵入性诊断方法。
Thrombospondin type I domain‐containing 7A (THSD7A), is a specific autoantigen of adult idiopathic membranous nephropathy (IMN), whose circulating antibody (THSD7A‐AB) represents a promising biomarker for diagnosis of IMN. The objective of this meta‐analysis is to investigate the diagnostic efficiency of THSD7A‐AB for IMN. After rigorous data extraction, quality assessment, and data analysis, 10 articles (4545 patients) are included. For IMN, the summary sensitivity is 4% (2–7%), and the specificity is 99% (98–100%). The summary positive likelihood ratio (PLR) and negative likelihood ratio (NLR) are 5.40 (2.40–11.90) and 0.97 (0.95–0.99), respectively. The diagnostic odds ratio (DOR) is 6.00 (2.00–12.00). The area under the summary receiver operating characteristic curve (AUC) is 0.78 (0.74–0.81). For M‐type phospholipase A2 receptor (PLA2R)‐negative IMN, the summary sensitivity is 8% (6–10%), specificity is 100% (99–100%). The summary PLR and NLR are 15.80 (5.70–44.00) and 0.93 (0.91–0.95), respectively. The DOR is 17.00 (6.00–48.00). The AUC is 0.99 (0.98–1.00). THSD7A‐AB has higher diagnostic value in PLA2R‐negative patients than in IMN patients. These results suggest that THSD7A‐AB could possibly be applied as an auxiliary non‐invasive diagnostic method for PLA2R‐negative IMN. The present meta‐analysis systematically assesses the diagnostic efficiency of THSD7A‐AB testing in patients with adult idiopathic membranous nephropathy (IMN) for the first time. It is found that thrombospondin type I domain‐containing 7A (THSD7A)‐AB has a higher diagnostic value for M‐type phospholipase A2 receptor (PLA2R)‐negative patients than for IMN patients. THSD7A‐AB testing can be applied as an auxiliary non‐invasive diagnostic method for PLA2R‐negative IMN.
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