APOLIPOPROTEIN-E EPSILON-4 ALLELE IS ASSOCIATED WITH DEPOSITION OF AMYLOID BETA-PROTEIN FOLLOWING HEAD-INJURY
APOLIPOPROTEIN-E EPSILON-4 ALLELE IS ASSOCIATED WITH DEPOSITION OF AMYLOID BETA-PROTEIN FOLLOWING HEAD-INJURY
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DOI：
10.1038/nm0295-135
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发表时间：
1995-02-01
期刊：
影响因子：
82.9
通讯作者：
GRAHAM, DI
中科院分区：
文献类型：
--
作者：
NICOLL, JAR;ROBERTS, GW;GRAHAM, DI
淀粉样β蛋白（A β）在脑中的沉积在阿尔茨海默病的发病机制中起着关键作用。载脂蛋白E β 4等位基因（apo E-ap 4）是阿尔茨海默病的一个强危险因素，有体外证据表明apo E直接参与A β沉积。头部损伤是阿尔茨海默病的流行病学风险因素，并且在严重头部损伤后死亡的个体中约有三分之一发生A β沉积。我们在这里报告说，在头部损伤后A β沉积的个体中，apo E-B4的频率（0.52）高于大多数阿尔茨海默病研究，而在头部损伤后没有A β沉积的个体中，apo E-B4的频率（0.16）与没有阿尔茨海默病的对照组相似（P < 0.00001）。这一发现提供了进一步的证据，将载脂蛋白E-beta 4与体内A β沉积联系起来，并表明已知的阿尔茨海默病的环境和遗传风险因素可能具有相加作用。此外，我们的发现表明，头部受伤的影响具有遗传易感性。
Deposition of amyloid beta-protein (A beta) in the brain plays a key role in the pathogenesis of Alzheimer's disease. Apolipoprotein E epsilon 4 allele (apo E-epsilon 4) is a strong risk factor for Alzheimer's disease, and there is in vitro evidence that apo E is directly involved in A beta deposition. Head injury is an epidemiological risk factor for Alzheimer's disease and deposition of A beta occurs in approximately one-third of individuals dying after a severe head injury. We report here that the frequency of apo E-epsilon 4 in those individuals with A beta deposition following head injury (0.52) is higher than in most studies of Alzheimer's disease, while in those head-injured individuals without A beta deposition the apo E-epsilon 4 frequency (0.16) is similar to controls without Alzheimer's disease (P < 0.00001). This finding provides further evidence linking apo E-epsilon 4 with A beta deposition in vivo and suggests that known environmental and genetic risk factors for Alzheimer's disease may act additively. In addition our finding indicates a genetic susceptibility to the effects of a head injury.