Control of solvent use in medical devices by proton transfer reaction mass spectrometry and ion molecule reaction mass spectrometry.
Control of solvent use in medical devices by proton transfer reaction mass spectrometry and ion molecule reaction mass spectrometry.
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DOI：
10.1016/j.jpba.2009.04.020
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发表时间：
2009-09
影响因子：
3.4
通讯作者：
Yujie Wang;Hai-yan Han;Chengyin Shen;Jian-quan Li;Hongmei Wang;Y. Chu
中科院分区：
文献类型：
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作者：
Yujie Wang;Hai-yan Han;Chengyin Shen;Jian-quan Li;Hongmei Wang;Y. Chu
应用国产质子转移反应质谱仪（PTR-MS）和市售离子分子反应质谱仪（IMR-MS）对聚氯乙烯（PVC）塑料输液器包装袋中的挥发性有机化合物（VOCs）进行了检测。PTR-MS和IMR-MS测量中最丰富的特征离子分别在m/z 99和98处，这是残留化学物质在PTR-MS中发生质子转移反应和IMR-MS中发生电荷转移反应的软电离的结果。根据PTR-MS调查中离子强度对还原场的依赖，残留物可以明确地识别为环己酮，一种PVC医疗器械制造中常用的粘合剂。经PTR-MS定量测定，两种输液器包装中环己酮的浓度分别为11 ppm和20ppm。PTR-MS和IMR-MS检测方法具有响应速度快、检测绝对浓度高、灵敏度高等特点，可用于检测环己酮等化学溶剂的非法或过量使用等医疗器械的质量控制。
A homemade proton transfer reaction mass spectrometer (PTR-MS) and a commercial ion molecule reaction mass spectrometer (IMR-MS) have been applied to detect volatile organic compounds (VOCs) in the packaging bags of infusion sets made of polyvinylchloride (PVC) plastic. The most abundant characteristic ions in the PTR-MS and IMR-MS measurements are observed at m/z 99 and 98 respectively, which are the results of soft ionizations that a residual chemical undergoes the proton transfer reaction in PTR-MS and the charge transfer reaction in IMR-MS. On the basis of ionic intensity dependence on the reduced-field in the PTR-MS investigation, the residue can be unambiguously identified as cyclohexanone, a commonly used adhesive agent in PVC medical device manufacture. Quantitative measurement by PTR-MS shows that concentrations of cyclohexanone in the packages of two types of infusion sets are 11 and 20ppm respectively. Due to fast response, absolute concentration detection, and high sensitivity, the PTR-MS and IMR-MS detection methods are proposed for the quality control of medical devices including the detection of illegal or excessive uses of chemical solvents like cyclohexanone.