The use of chitin and chitosan as drug carriers.
The use of chitin and chitosan as drug carriers.
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DOI：
10.1248/cpb.29.3067
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发表时间：
1981-10
影响因子：
1.7
通讯作者：
S. Miyazaki;K. Ishii;T. Nadai
中科院分区：
文献类型：
--
作者：
S. Miyazaki;K. Ishii;T. Nadai
考察了甲壳素和壳聚糖作为药物缓释载体的适宜性。以吲哚美辛和盐酸罂粟碱为模型药物进行评价。药物从干燥凝胶中获得缓释。分散在壳聚糖凝胶中的药物以恒定速率（零级）释放。甲壳素和壳聚糖可作为药物缓释的有效载体。
The suitability of chitin and chitosan for use as vehicles for the sustained release of drugs was examined. Indomethacin and papaverine hydrochloride were used as model drugs in this evaluation. Sustained release of the drugs from the dried gels was obtained. Drugs dispersed in the chitosan gels were released at a constant rate (zero order). Chitin and chitosan could be useful vehicles for the sustained release of drugs.