Synthesis of α-Alkenyl α,β-Unsaturated Ketones via Dehydrogermylation of Oxagermacycles with Regeneration of the Germanium(II) Species
Synthesis of α-Alkenyl α,β-Unsaturated Ketones via Dehydrogermylation of Oxagermacycles with Regeneration of the Germanium(II) Species
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通过 Oxagermacycles 脱氢甲酰化合成 α-烯基 α,β-不饱和酮并再生锗 (II) 物质
DOI：
10.1021/acs.orglett.9b03454
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Yasuda Makoto
中科院分区：
文献类型：
--
作者：
Minami Yohei;Konishi Akihito;Yasuda Makoto
报道了用锗盐合成α-烯基α，β-不饱和酮的方法。α，β-不饱和酮与锗盐和醛反应生成的氧杂锗杂环可转化为α-烯基α，β-不饱和酮。铵盐促进了Ge（II）物种的消除，以良好的产率得到两类α-烯基α，β-不饱和酮。α-烯基α，β-不饱和酮是多取代杂环的前体。
The synthesis of α-alkenyl α,β-unsaturated ketones using germanium(II) salts is reported. Oxagermacycles derived from α,β-unsaturated ketones with germanium(II) salts and aldehydes can be transformed into α-alkenyl α,β-unsaturated ketones. Ammonium salts promoted the elimination of Ge(II) species to afford the two classes of α-alkenyl α,β-unsaturated ketones in good yields. The α-alkenyl α,β-unsaturated ketones are precursors for multisubstituted heterocycles.