HAS THE CHANGE TO BETA-AGONISTS COMBINED WITH ORAL THEOPHYLLINE INCREASED CASES OF FATAL ASTHMA?
HAS THE CHANGE TO BETA-AGONISTS COMBINED WITH ORAL THEOPHYLLINE INCREASED CASES OF FATAL ASTHMA?
复制标题
改变β受体激动剂并结合口服茶碱是否会增加致命性哮喘病例？
DOI：
10.1016/s0140-6736(81)92403-x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
A. Thomas
中科院分区：
文献类型：
--
作者：
J. Wilson;D. Sutherland;A. Thomas
过去两年，奥克兰因急性哮喘突然死亡的年轻人明显增加。审查了 22 例死亡病例。新西兰哮喘治疗的处方习惯一直在改变，口服茶碱药物的使用大幅增加，特别是缓释制剂，在许多患者中已经取代了吸入类固醇和色甘酸。有人建议，茶碱和高剂量吸入β2受体激动剂之间可能存在叠加毒性，导致心脏骤停。此外，当用支气管扩张剂定期对症治疗取代吸入类固醇或色甘酸时，患者对哮喘危象的感知可能会延迟。
An apparent increase in young people dying suddenly from acute asthma has been noted in the past 2 years in Auckland. 22 fatal cases were reviewed. Prescribing habits for asthma therapy have been changing in New Zealand, with a considerable increase in the use of oral theophylline drugs, particularly sustained-release preparations, which in many patients have replaced inhaled steroids and cromoglycate. It is suggested that there may be an additive toxicity between theophylline and inhaled β2-agonists at high doses which produces cardiac arrest. Also when regular symptomatic treatment with bronchodilators replaces inhaled steroids or cromoglycate the patient's perception of an asthma crisis may be delayed.