Clinical epidemiology for childhood primary central nervous system tumors
Clinical epidemiology for childhood primary central nervous system tumors
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DOI：
10.1007/s11060-008-9740-0
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发表时间：
2009-03-01
影响因子：
3.9
通讯作者：
Dhellemmes, Patrick
中科院分区：
文献类型：
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作者：
Bauchet, Luc;Rigau, Valerie;Dhellemmes, Patrick
这项工作由法国脑肿瘤数据库（FBTDB）进行，旨在前瞻性记录法国所有原发性中枢神经系统肿瘤（PCNST），可进行组织学诊断。有关儿童的结果。本研究分析了FBTDB记录的2004-2006年期间新诊断并经组织学证实的PCNST儿童病例（0-19岁）。法国所有神经病理学和神经外科部门都参加了这一计划。神经外科医生和神经病理学家完成了包含社会人口统计学、临床、放射学和解剖病理学信息的数据文件。Herault的肿瘤登记处被授权使用个人标识符编辑数据文件。记录了约1，017例（533名男孩和484名女孩）新诊断的儿童PCNST（胶质瘤：52%，所有其他神经上皮肿瘤：31%，颅咽管瘤：5%，生殖细胞肿瘤，脑膜瘤和神经鞘瘤：各约3%，所有组织学亚型均已详细说明）。肿瘤切除率为83.3%，活检率为16.7%。详细介绍了按组织学、样本冷冻保存、年龄、性别、肿瘤部位和手术进行的分布。据我们所知，这项工作是欧洲第一个专门用于PCNST的数据库，其中包括收集临床，放射学和组织学数据（包括标本的冷冻保存）。FBTDB的长期目标是建立一个国家登记册和网络，以进行流行病学研究，实施临床和基础研究方案，并评估和协调受PCNST影响的儿童和成人患者的医疗保健。
This work was conducted by the French Brain Tumor Data Bank (FBTDB) and aims to prospectively record all primary central nervous system tumors (PCNST), in France, for which histological diagnosis is available. Results concerning children are presented. This study analyzes the childhood cases (0-19 years) of newly diagnosed and histologically confirmed PCNST (during the years 2004-2006) which have been recorded by the FBTDB. All French neuropathology and neurosurgery departments participated in this program. Neurosurgeons and neuropathologists completed a data file containing socio-demographic, clinical, radiologic and anatomopathologic information. The Tumor Registry from Herault was authorized to compile the data files with personal identifiers. About 1,017 cases (533 boys and 484 girls) of newly diagnosed childhood PCNST have been recorded (gliomas: 52%, all other neuroepithelial tumors: 31%, craniopharyngioma: 5%, germ cell tumors, meningioma and neurinoma: approximately 3% each, all histological subtypes have been detailed). Tumor resections were performed in 83.3%, and biopsies in 16.7%. The distributions by histology, cryopreservation of the samples, age, sex, tumor site and surgery have been detailed. To our knowledge, this work is the first databank in Europe dedicated to PCNST that includes the collection of clinical, radiological and histological data (including cryopreservation of the specimen). The long term goals of the FBTDB are to create a national registry and a network to perform epidemiological studies, to implement clinical and basic research protocols, and to evaluate and harmonize the healthcare of children and adult patients affected by PCNST.