Novel advances in drug delivery to brain cancer
Novel advances in drug delivery to brain cancer
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DOI：
10.1177/153303460500400409
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发表时间：
2005-08-01
影响因子：
2.8
通讯作者：
Lesniak, MS
中科院分区：
文献类型：
--
作者：
Lesniak, MS
脑肿瘤的治疗一直受到缺乏有效的药物递送到大脑的方法的限制。全身给药通常与毒副作用相关，并且最终无法在肿瘤内达到治疗浓度。一个有吸引力的策略，已经获得了重要的脑肿瘤治疗依赖于局部和控制交付的化疗药物的生物可降解聚合物。这种技术允许肿瘤细胞直接暴露于治疗剂延长一段时间，并已被证明可以延长恶性脑肿瘤患者的生存期。使用聚合物进行局部药物递送极大地扩展了可用于治疗恶性脑肿瘤的药物谱。这篇综述讨论了局部给药的基本原理，介绍了目前可用的聚合物为基础的治疗药物的发展，并强调了有前途的非聚合物为基础的药物输送方法用于治疗恶性脑肿瘤的例子。
The therapy of brain tumors has been limited by a lack of effective methods of drug delivery to the brain. Systemic administration is often associated with toxic side effects and ultimately fails to achieve therapeutic concentrations within a tumor. An attractive strategy that has gained importance in brain tumor therapy has relied on local and controlled delivery of chemotherapeutic agents by biodegradable polymers. This technique allows direct exposure of tumor cells to a therapeutic agent for a prolonged period of time and has been shown to prolong the survival of patients with malignant brain tumors. The use of polymers for local drug delivery greatly expands the spectrum of drugs available for the treatment of malignant brain tumors. This review discusses the rationale for local drug delivery, describes the development of currently available polymer-based therapeutic agents, and highlights examples of promising non-polymer based drug delivery methods for use in the treatment of malignant brain tumors.