INSULIN-SECRETION AND SENSITIVITY IN HYPERTHYROIDISM
INSULIN-SECRETION AND SENSITIVITY IN HYPERTHYROIDISM
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DOI：
10.1055/s-2007-1009208
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发表时间：
1989-05-01
影响因子：
2.2
通讯作者：
WON, JGS
中科院分区：
文献类型：
--
作者：
JAP, TS;HO, LT;WON, JGS
为了检查甲状腺功能亢进症对碳水化合物代谢的影响，我们研究了8名格雷夫斯病受试者在甲状腺功能亢进症治疗前后以及8名年龄、性别和体重匹配的正常受试者的葡萄糖刺激的胰岛素分泌和葡萄糖利用。Graves病患者血清甲状腺素（24.81±2.44 ug/dl，平均值±SEM）和三碘甲状腺原氨酸（459±5.5 ng/dl，平均值±SEM）水平显著升高。同时测定空腹期间和75 g口服葡萄糖负荷后每30分钟至180分钟的血糖、血清胰岛素和C肽水平。此外，在正常葡萄糖钳夹期间，以40 mU/m2 min-1的胰岛素输注，测定血浆葡萄糖、血清胰岛素和血清C肽。
To examine the effect of hyperthyroidism on carbohydrate metabolism, we studied glucose-stimulated insulin secretion and glucose utilization in 8 subjects with Graves' disease before and after treatment for hyperthyroidism and 8 age-, sex-and weight-matched normal subjects. Subjects with Graves' disease had significant elevated serum levels of thyroxine (24.81±2.44 ug/dl, mean±SEM) and triiodothyronine (459±5.5 ng/dl, mean±SEM). Simultaneous measurement of plasma glucose, serum insulin and C-peptide levels during fasting and every 30 minutes up to 180 minutes after 75 g oral glucose loading was determined. In addition, plasma glucose, serum insulin and serum C-peptide were measured during euglycemic glucose clamp with insulin infusion of 40 mU/m 2 min-1.