Distance dependency of exciton coupled circular dichroism using turn and helical peptide spacers.
Distance dependency of exciton coupled circular dichroism using turn and helical peptide spacers.
复制标题
使用转角和螺旋肽间隔基的激子耦合圆二色性的距离依赖性。
作者：
S. Oancea;F. Formaggio;S. Campestrini;Q. Broxterman;B. Kaptein;C. Toniolo
卟啉类化合物是一种很有前途的发色团，可用于激子耦合圆二色性（CD）方法研究蛋白质的三维结构。本文报道了一种以同型寡-[L-（alphaMe）瓦尔]（n）肽为刚性间隔基的双卟啉模型体系的合成、红外光谱和核磁共振表征以及圆二色谱性质。特别是，耦合CD现象的实验检测，其强度调制的发色团间的距离。这些结果扩展和整合了类固醇，二聚体类固醇和短毒素桥的报道。
Porphyrins are promising chromophores for the investigation of the still unexplored area of 3-dimensional structural studies of proteins by using the exciton coupled circular dichroism (CD) method. The synthesis, conformational characterization by FTIR absorption and (1)H-NMR, and CD properties are described for a model bis-porphyrin system based on homooligo-[L-(alphaMe)Val](n) peptides as rigid spacers. In particular, the coupled CD phenomenon is experimentally detected, the intensity of which is modulated by the interchromophoric distance. These results extend and integrate those already reported with steroid, dimeric steroid, and brevetoxin bridges.
影响因子：
2.9
作者：
KARLE, IL;BALARAM, P
通讯作者：
BALARAM, P
影响因子：
2
作者：
Huang, XF;Nakanishi, K;Berova, N
通讯作者：
Berova, N