An epidemiological study of pulmonary arterial hypertension
An epidemiological study of pulmonary arterial hypertension
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DOI：
10.1183/09031936.00092306
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发表时间：
2007-07-01
影响因子：
24.3
通讯作者：
Stewart, S.
中科院分区：
文献类型：
--
作者：
Peacock, A. J.;Murphy, N. F.;Stewart, S.
对苏格兰人群中因肺动脉高压（PAH）而住院的所有患者进行检查，以确定PAH的流行病学特征。将这些数据与苏格兰肺血管单位（SPVU）的专家数据进行比较。使用关联的苏格兰发病率记录方案，确定了1986-2001年期间因PAH（特发性PAH、先天性心脏异常相关的肺动脉高压和结缔组织疾病相关的肺动脉高压）入院的所有16-65岁成人的数据。将这些数据与SPVU数据库（2005年）中的最新数据进行比较。总体而言，1986-2001年期间，374名16-65岁的苏格兰男性和女性因PAH事件住院。PAH的年发病率为7.1例/百万人口。2002年12月31日，有165例存活病例，PAH患病率为每百万人口52例。可从SPVU获得1997-2006年的数据。在2005年，最后一年有完整的数据集，PAH的发病率为7.6例/百万人口，相应的患病率为26例/百万人口，苏格兰Morphology Record计划的住院数据显示肺动脉高压的患病率高于专家中心（苏格兰和法国）的数据。住院数据可能高估了人群中肺动脉高压的真实频率，但专家中心也可能低估了真实频率。
All hospitalisations for pulmonary arterial hypertension (PAH) in the Scottish population were examined to determine the epidemiological features of PAH. These data were compared with expert data from the Scottish Pulmonary Vascular Unit (SPVU).Using the linked Scottish Morbidity Record scheme, data from all adults aged 16-65 yrs admitted with PAH (idiopathic PAH, pulmonary hypertension associated with congenital heart abnormalities and pulmonary hypertension associated with connective tissue disorders) during the period 1986-2001 were identified. These data were compared with the most recent data in the SPVU database (2005).Overall, 374 Scottish males and females aged 16-65 yrs were hospitalised with incident PAH during 1986-2001. The annual incidence of PAH was 7.1 cases per million population. On December 31, 2002, there were 165 surviving cases, giving a prevalence of PAH of 52 cases per million population. Data from the SPVU were available for 1997-2006. In 2005, the last year with a complete data set, the incidence of PAH was 7.6 cases per million population and the corresponding prevalence was 26 cases per million population.Hospitalisation data from the Scottish Morbidity Record scheme gave higher prevalences of pulmonary arterial hypertension than data from the expert centres (Scotland and France). The hospitalisation data may overestimate the true frequency of pulmonary arterial hypertension in the population, but it is also possible that the expert centres underestimate the true frequency.