Contributions of the amygdala and medial prefrontal cortex to incentive cue responding
Contributions of the amygdala and medial prefrontal cortex to incentive cue responding
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DOI：
10.1016/j.neuroscience.2008.06.037
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发表时间：
2008-08-26
期刊：
影响因子：
3.3
通讯作者：
Fields, H. L.
中科院分区：
文献类型：
--
作者：
Ishikawa, A.;Ambroggi, F.;Fields, H. L.
寻求奖励的行为是由神经回路控制的，这些回路包括杏仁核基底外侧核（BLA）、内侧前额叶皮质（mPFC）、伏隔核（NAc）和腹侧被盖区。利用一种辨别性刺激（DS）任务，在该任务中，间歇性呈现的线索（DS）引导大鼠对蔗糖做出操作性反应，我们先前已经证明，伏隔核中的多巴胺受体拮抗作用会减少对强化线索的反应，而伏隔核的普遍失活会在没有线索的情况下增加行为反应。因为它们向伏隔核发送主要的谷氨酸能投射，所以杏仁核基底外侧核和内侧前额叶皮质也可能有助于伏隔核所调节的寻求奖励行为。在这项研究中，我们比较了杏仁核基底外侧核和内侧前额叶皮质失活对大鼠执行辨别性刺激任务表现的影响。通过联合使用γ - 氨基丁酸A（GABAA）和γ - 氨基丁酸B（GABAB）激动剂使杏仁核基底外侧核失活，会损害对线索的反应，而在没有线索的情况下对操作性行为的影响极小。背内侧前额叶皮质（dmPFC）失活也抑制了线索诱发的寻求奖励行为。相比之下，腹内侧前额叶皮质（vmPFC）失活会解除对无奖励线索反应的抑制，而对强化线索反应的影响较小。这些发现表明，杏仁核基底外侧核和背内侧前额叶皮质促进线索诱发的寻求奖励行为，而在同一任务中，腹内侧前额叶皮质对无奖励行为施加抑制性控制。（C）2008国际脑研究组织。由爱思唯尔有限公司出版。保留所有权利。
Reward-seeking behavior is controlled by neuronal circuits that include the basolateral nucleus of amygdala (BLA), medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and ventral tegmental area. Using a discriminative stimulus (DS) task in which an intermittently presented cue (DS) directs rats to make an operant response for sucrose, we previously demonstrated that dopamine receptor antagonism in the NAc reduced reinforced cue responding, whereas general inactivation of the NAc increased behavioral responding in the absence of the cue. Because they send major glutamatergic projections to the NAc, the BLA and mPFC may also contribute to reward-seeking behaviors modulated by the NAc. In this study we compare the effects of BLA and mPFC inactivation on rats' performance of a DS task. BLA inactivation by combined GABAA and GABAB agonists impaired cue responding with minimal effects on operant behavior in the absence of cues. Dorsal medial prefrontal cortex (dmPFC) inactivation also inhibited cue-evoked reward-seeking. In contrast, ventral medial prefrontal cortex (vmPFC) inactivation disinhibited responding to unrewarded cues with less influence on reinforced cue responding. These findings demonstrate that the BLA and dmPFC facilitate cue-evoked reward-seeking, whereas, in the same task the vmPFC exerts inhibitory control over unrewarded behaviors. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.