SIMULATIONS OF A VENTROLATERAL MEDULLARY NEURAL-NETWORK FOR RESPIRATORY RHYTHMOGENESIS INFERRED FROM SPIKE TRAIN CROSS-CORRELATION
SIMULATIONS OF A VENTROLATERAL MEDULLARY NEURAL-NETWORK FOR RESPIRATORY RHYTHMOGENESIS INFERRED FROM SPIKE TRAIN CROSS-CORRELATION
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DOI：
10.1007/bf00200329
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发表时间：
1994-02-01
影响因子：
1.9
通讯作者：
LINDSEY, BG
中科院分区：
文献类型：
--
作者：
BALIS, UJ;MORRIS, KF;LINDSEY, BG
将从锋电位序列分析推断出的腹外侧髓呼吸神经元之间的连接纳入模型中，并使用程序WDM 11（MacGregor 1987）进行模拟。吸气（I）和呼气（E）神经元与递增（AUG）和递减（DEC）的放电模式和吻I-E/I神经元表现出不同程度的适应，但没有内源性爆发的性质。调整模拟参数，使呼吸相持续时间，神经元放电模式，和短时间尺度的相关性是类似的麻醉，迷走神经切断，成年猫相应的测量。当每一组连接的强度在一个较小的有效值上增加100%时，节律发生持续存在。相位持续时间和放电模式的变化所造成的操纵连接强度或人口活动导致了几个预测。(a)I-E/I群的激发在吸气相之后。(b)在缺乏I-E/I活动的情况下，可以通过I-DEC和I-AUG神经元的非模式化兴奋来重建节律活动。(9)I-DEC神经元活动的增加可导致无气呼吸模式。(d)I-DEC神经元活动的减少增加了吸气斜坡的斜率并缩短了吸气。(e)E-DEC群体的兴奋会使呼气相延长或产生呼吸暂停; E-DEC神经元的抑制会减少呼气时间。(f)E-AUG细胞的兴奋导致I-AUG神经元在其活跃期开始时表现出阶跃而不是斜坡式的放电率增加。结果表明，呼吸和神经元放电模式的每个阶段的持续时间可能受到调节的机制。
Connections among ventrolateral medullary respiratory neurons inferred from spike train analysis were incorporated into a model and simulated with the program SYSTM11 (MacGregor 1987). Inspiratory (I) and expiratory (E) neurons with augmenting (AUG) and decrementing (DEC) discharge patterns and rostral I-E/I neurons exhibited varying degrees of adaptation, but no endogenous bursting properties. Simulation parameters were adjusted so that respiratory phase durations, neuronal discharge patterns, and short-time scale correlations were similar to corresponding measurements from anesthetized, vagotomized, adult cats. Rhythmogenesis persisted when the strength of each set of connections was increased 100% over a smaller effective value. Changes in phase durations and discharge patterns caused by manipulation of connection strengths or population activity led to several predictions. (a) Excitation of the I-E/I population prolongs the inspiratory phase. (b) Rhythmic activity can be reestablished in the absence of I-E/I activity by unpatterned excitation of I-DEC and I-AUG neurons. (9) An increase in I-DEC neuron activity can cause an apneustic respiratory pattern. (d) A decrease in I-DEC neuron activity increases the slope of the inspiratory ramp and shortens inspiration. (e) Excitation of the E-DEC population prolongs the expiratory phase or produces apnea; inhibition of E-DEC neurons reduces expiratory time. (f) Excitation of E-AUG cells causes I-AUG neurons to exhibit a step rather than a ramp increase in firing rate at the onset of their active phase. The results suggest mechanisms by which the duration of each phase of breathing and neuronal discharge patterns may be regulated.