Ramadan fasting ameliorates arterial pulse pressure and lipid profile, and alleviates oxidative stress in hypertensive patients
Ramadan fasting ameliorates arterial pulse pressure and lipid profile, and alleviates oxidative stress in hypertensive patients
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DOI：
10.3109/08037051.2013.836808
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发表时间：
2014-06-01
期刊：
影响因子：
1.8
通讯作者：
Al-Shafei, Ahmad I. M.
中科院分区：
文献类型：
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作者：
Al-Shafei, Ahmad I. M.
背景和目标。斋月禁食对健康的影响很重要。其对动脉脉压（PP），血脂和氧化应激的影响在高血压患者的特点。方法.在禁食前、禁食期间和禁食后，在相同的（各40名）、性别和年龄匹配的高血压患者（HT）组和对照组（C）组（年龄55 +/- 5岁）中测量PP、脂质谱指数和氧化应激。结果禁食使HT组和C组的PP分别显著降低17.2%和9.3%，但不显著。总胆固醇（TC）在HT和C患者中分别降低了11.7%和4.7%，但不显著。HT组和C组甘油三酯（TG）和丙二醛（MDA）分别降低24.5%和22.8%，MDA降低45.6%和54.3%，谷胱甘肽（GSH）分别升高56.8%和52.6%。高密度脂蛋白（HDL）显著升高33.3%，不显著升高6.7%，而低密度脂蛋白（LDL）显著降低17.7%，不显著降低4.0%。禁食6周后，HT组和C组的MDA仍显著低于禁食前水平24.3%和25.7%，GSH分别升高30.2%和26.3%，而PP和TC在两组中均恢复至禁食前水平。空腹后高密度脂蛋白（HDL）较空腹水平升高20.3%，低密度脂蛋白（LDL）较空腹水平降低12.0%。结论禁食可改善高血压患者的PP和血脂水平，并改善氧化应激。
Background and aim. Effects of Ramadan fasting on health are important. Its effects on arterial pulse pressure (PP), lipid profile and oxidative stress were characterized in hypertensives. Methods. PP, indices of lipid profile and oxidative stress were measured pre-, during and post-fasting in equal (40 each), sex-and age-matched groups (age 55 +/- 5 years) of hypertensives (HT) and controls (C). Results. Fasting reduced PP significantly by 17.2% and insignificantly by 9.3% in the HT and C groups, respectively. Total cholesterol (TC) was lowered insignificantly by 11.7% and 4.7% in the HT and C patients, respectively. Triglycerides (TG) and malondialdehyde (MDA) were significantly lowered by: TG: 24.5% and 22.8%; MDA: 45.6% and 54.3%; while glutathione (GSH) elevated by 56.8% and 52.6% in the HT and C groups, respectively. High-density lipoproteins (HDL) were raised significantly by 33.3% and insignificantly by 6.7%, whereas low-density lipoproteins (LDL) decreased significantly by 17.7% and insignificantly by 4.0% in the HT and C groups, respectively. At 6 weeks post-fasting, MDA remained significantly lower than the pre-fasting level by 24.3% and 25.7%, and GSH higher by 30.2% and 26.3% in the HT and C groups, respectively, while PP and TC returned to pre-fasting values in both groups. The post-fasting, HDL was significantly higher by 20.3% and LDL lower by 12.0% than the fasting levels in the HT patients. Conclusion. Fasting improves PP and lipids profile and ameliorates oxidative stress in hypertensives.