Macrophage Ia antigens. I. macrophage populations differ in their expression of Ia antigens.
Macrophage Ia antigens. I. macrophage populations differ in their expression of Ia antigens.
复制标题
巨噬细胞 Ia 抗原。
作者：
C. Cowing;B. Schwartz;H. Dickler
通过间接免疫荧光和微量细胞毒性，它表明，不同群体的小鼠巨噬细胞膜上携带不同数量的Ia抗原。至少可以区分三个亚群：缺乏Ia抗原并在腹膜渗出液中占主导地位的亚群;携带I-A抗原的细胞，其是脾巨噬细胞的大多数，在腹膜中占少数;以及携带I-C抗原的细胞，其是脾和腹膜中的少数群体。内部放射性同位素标记研究证实，I区分子由巨噬细胞合成。这表明，这些不同的巨噬细胞亚群可能在免疫反应中发挥不同的作用。
By indirect immunofluorescence and microcytotoxicity it was demonstrated that different populations of murine macrophages bear different amounts of Ia antigens on their membranes. At least three subpopulations could be distinguished: those that lack Ia antigens and predominate in peritoneal exudate; cells bearing I-A antigens that are the majority of splenic macrophages and a minor population in the peritoneum; and cells bearing I-C antigens that are a minor population in both spleen and peritoneum. Internal radioisotope labeling studies confirmed that the I region molecules are synthesized by the macrophages. It is suggested that these different macrophage subpopulations may play distinct roles in the immune response.