Olfactory modulation of affective touch processing - A neurophysiological investigation
Olfactory modulation of affective touch processing - A neurophysiological investigation
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DOI：
10.1016/j.neuroimage.2016.04.046
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发表时间：
2016-07-15
期刊：
影响因子：
5.7
通讯作者：
Olausson, Hakan
中科院分区：
文献类型：
--
作者：
Croy, Ilona;Drechsler, Edda;Olausson, Hakan
触摸可以是高度情绪化的，根据环境的不同，它可以被认为是愉快和舒适的，也可以被认为是恶心和危险的。在这里，我们研究了触觉刺激的处理使用功能性磁共振成像（fMRI）范式的影响。这是通过在一个可变的嗅觉环境中嵌入触觉刺激来实现的。20个人在接受以下刺激块的同时进行BOLD fMRI扫描：缓慢抚摸，Civette气味（粪便样），Rose气味，Touch + Civette和Touch + Rose。收集触觉刺激的愉悦度和强度评分以及嗅觉刺激的厌恶度和强度评分。使用协方差分析研究了嗅觉环境对触觉处理的影响。采用心理生理交互作用分析（PPI）评价嗅觉加工区和躯体感觉加工区之间的耦合，主观厌恶的嗅觉环境显著降低了触觉的愉悦感。触觉功能磁共振成像激活的次级躯体感觉皮层，operculum 1（OP 1），对气味的厌恶呈正相关。触觉愉悦度下降与后丘脑活动减少有关。PPI分析揭示了一个显着的相互作用之间的OP 1，后额叶，和区域处理厌恶的气味（眶额皮质和杏仁核）。我们的结论是厌恶的嗅觉环境的评价适度的神经反应，在躯体感觉区域的OP 1的上调和下调后额叶。情感触摸处理的这种自适应调节可以促进对潜在有害刺激的自适应反应。(C)2016 Elsevier Inc. All rights reserved.
Touch can be highly emotional, and depending on the environment, it can be perceived as pleasant and comforting or disgusting and dangerous. Here, we studied the impact of context on the processing of tactile stimuli using a functional magnetic resonance imaging (fMRI) paradigm. This was achieved by embedding tactile stimulation in a variable olfactory environment.Twenty people were scanned with BOLD fMRI while receiving the following stimulus blocks: Slow stroking Touch, Civette odor (feces like), Rose odor, Touch + Civette, and Touch + Rose. Ratings of pleasantness and intensity of tactile stimuli and ratings of disgust and intensity of olfactory stimuli were collected. The impact of the olfactory context on the processing of touch was studied using covariance analyses. Coupling between olfactory processing and somatosensory processing areas was assessed with psychophysiological interaction analysis (PPI).A subjectively disgusting olfactory environment significantly reduced the perceived pleasantness of touch. The touch fMRI activation in the secondary somatosensory cortex, operculum 1 (OP1), was positively correlated with the disgust towards the odors. Decreased pleasantness of touch was related to decreased posterior insula activity. PPI analysis revealed a significant interaction between the OP1, posterior insula, and regions processing the disgust of odors (orbitofrontal cortex and amygdala).We conclude that the disgust evaluation of the olfactory environment moderates neural reactivity in somatosensory regions by upregulation of the OP1 and downregulation of the posterior insula. This adaptive regulation of affective touch processing may facilitate adaptive reaction to a potentially harmful stimulus. (C) 2016 Elsevier Inc. All rights reserved.