Antibody-Dependent Enhancement Occurs Upon Re-Infection with the Identical Serotype Virus in Feline Infectious Peritonitis Virus Infection
Antibody-Dependent Enhancement Occurs Upon Re-Infection with the Identical Serotype Virus in Feline Infectious Peritonitis Virus Infection
复制标题
DOI：
10.1292/jvms.70.1315
复制
发表时间：
2008-12-01
影响因子：
1.2
通讯作者：
Hohdatsu, Tsutomu
中科院分区：
文献类型：
--
作者：
Takano, Tomomi;Kawakami, Chisako;Hohdatsu, Tsutomu
猫传染性腹膜炎病毒（FIPV）根据S蛋白的氨基酸序列分为血清I型和血清II型。已报道了在存在FIPV S蛋白抗体的情况下，巨噬细胞感染的抗体依赖性增强（ADE），以及ADE与中和表位之间的密切关系。FIPV血清型差异对ADE诱导的重要性尚不清楚。在这项研究中，我们研究了是否相同或不同血清型的FIPV在猫中诱导ADE。无特定病原体的猫被动免疫与抗I型或II型FIPV抗体，我们研究了ADE的诱导与I型FIPV皮下接种后。使用FIPV血清型I的接种增强了FIPV血清型I特异性抗体被动免疫的猫中FIP的发作，但在那些被动免疫FIPV血清型II的抗体中没有。这些数据表明，相同血清型的再感染可诱导感染FIPV的猫发生ADE。
Feline infectious peritonitis virus (FIPV) is classified into serotype I and serotype II according to the amino acid sequence of its spike(S) protein. Antibody dependent enhancement (ADE) of macrophage infection Occurs in the presence of antibodies to FIPV S protein, and a close relationship between ADE and neutralizing epitopes has been reported. The importance of differences in FIPV serotype on the induction of ADE remains unclear. In this study, we investigated whether the same or different serotype of FIPV induces ADE in cats. Specific pathogen-free cats were passively immunized with anti-type I or II FIPV antibodies, and we investigated the induction of ADE following subcutaneous inoculation with type I FIPV. Inoculation using FIPV serotype I enhanced the onset of FIP in cats passively immunized with FIPV serotype I-specific antibodies but not in those passively immunized with antibodies to FIPV serotype II. These data suggest that re-infection with the same serotype induces ADE in cats infected with FIPV.