Catalytic asymmetric intramolecular hydroamination of aminoalkenes
Catalytic asymmetric intramolecular hydroamination of aminoalkenes
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DOI：
10.1016/j.tetlet.2007.07.117
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发表时间：
2007-09-17
影响因子：
1.8
通讯作者：
Tomioka, Kiyoshi
中科院分区：
文献类型：
--
作者：
Ogata, Tokutaro;Ujihara, Atsushi;Tomioka, Kiyoshi
氨基烯烃的不对称分子内环化由催化量的正丁基锂、二异丙胺和新设计的手性双恶唑啉在甲苯中催化，以定量产生高达 91% ee 的动力学控制的外环化胺。 (c) 2007 Elsevier Ltd. 保留所有权利。
Asymmetric intramolecular cyclization of aminoalkenes was catalyzed by a catalytic amount of n-butyllithium, diisopropylamine, and a newly designed chiral bisoxazoline in toluene to produce kinetically controlled exo-cyclized amines with up to 91% ee quantitatively. (c) 2007 Elsevier Ltd. All rights reserved.