HIV assembly and budding in macrophages
HIV assembly and budding in macrophages
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DOI：
10.1042/bst0370185
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发表时间：
2009-02-01
影响因子：
3.9
通讯作者：
Pelchen-Matthews, Annegret
中科院分区：
文献类型：
--
作者：
Marsh, Mark;Theusner, Kristina;Pelchen-Matthews, Annegret
包膜病毒颗粒的形成需要病毒的关键结构组分和病毒基因组RNA在组装新颗粒的细胞膜系统中聚集在一起。通过病毒结构蛋白和细胞蛋白之间的相互作用，运输事件以及随后的感染性病毒颗粒的组装和释放是协同的。在本论文中，我们考虑这些事件是如何发生在HIV在巨噬细胞中的生产过程中。在这些细胞中，病毒装配似乎发生在预先存在的被隔离在细胞内的特化质膜结构域上。在这些细胞内组装位点发生的事件可能赋予病毒独特的生物化学特征，并允许病毒释放通过感染性突触的形成来协调。
The formation of enveloped virus particles requires that key structural components of the virus, and the viral genomic RNA, are brought together at a cellular membrane system where new particles are assembled. The trafficking events, and the subsequent assembly and release of infectious virus particles, is co-coordinated through interactions between the viral structural proteins and cellular proteins. in the present paper, we consider how these events occur during HIV production in macrophages. in these cells, virus assembly appears to occur on a pre-existing specialized plasma membrane domain that is sequestered within the cells. The events that take place at these intracellular assembly sites may endow the virus with unique biochemical characteristics and allow virus release to be co-ordinated through the formation of infectious synapses.