Age at natural menopause and mortality
Age at natural menopause and mortality
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DOI：
10.1016/s1047-2797(97)00207-x
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发表时间：
1998-05-01
影响因子：
5.6
通讯作者：
Sandler, DP
中科院分区：
文献类型：
--
作者：
Cooper, GS;Sandler, DP
目得：本研究的目的是研究绝经年龄和死亡率之间的关联，在人口为基础的样本中的妇女在UnitedStates.METHODS：本研究是基于数据从国家健康和检查调查（NHANES）流行病学随访研究; 3191名妇女年龄在50-86岁。在平均4.0年的随访时间内，有345例死亡。我们使用年龄分层和泊松回归程序来评估自然绝经年龄的死亡风险，并对年龄、随访时间、种族、教育、吸烟和激素替代疗法的使用进行了调整。我们对双侧卵巢切除术的手术绝经进行了单独分析。与年龄在50岁或50岁以上的妇女相比，调整后的死亡率比（RR）为1.50（95%置信区间（CI），0.97-2.34）对于年龄< 40岁自然绝经的女性，1.04 40-44岁更年期者为0.96（95%CI，0.72-1.51），45-49岁更年期者为0.96（95%CI，0.72-1.26）。年龄在40-44岁自然绝经的女性发生癌症相关死亡的风险增加（校正RR 2.34，95%CI，1.20-4.58）。没有年龄相关的死亡风险增加被认为是妇女手术绝经与bilateral oophorectomy.CONCLUSIONS：这项研究提供了一些支持的音乐会，自然绝经年龄作为一个生物标志物的健康和衰老，与潜在的影响超出心血管疾病。出版社：Elsevier Science Inc.
PURPOSE: The purpose of this study was to examine the association between age at menopause and mortality in a population-based sample of women in the United States.METHODS: This study was based on data from the National Health and Examination Survey (NHANES) Epidemiologic Follow-up Study; 3191 women aged 50-86 years were included. There were 345 deaths over a mean follow-up time of 4.0 years. We used age stratified and Poisson regression procedures to assess mortality risk by age at natural menopause, with adjustment for age, duration of follow-up, race, education, smoking, and use of hormone replacement therapy. We conducted a separate analysis for surgical menopause with bilateral oophorectomy.RESULTS: Compared with women who were menstruating to age 50 or later, the adjusted mortality rate ratios (RR) were 1.50 (95% confidence interval(CI), 0.97-2.34) for women with a natural menopause at age < 40, 1.04 (95% CI, 0.72-1.51) for those with menopause at age 40-44, and 0.96 (95% CI, 0.72-1.26) for those with menopause at age 45-49. Women with a natural menopause at age 40-44 years experienced an increased risk of cancer-related mortality (adjusted RR 2.34, 95% CI, 1.20-4.58). No age-related increased mortality risk was seen among women who had surgical menopause with bilateral oophorectomy.CONCLUSIONS: This study provides some support for the concert that age at natural menopause serves as a biological marker of health and aging, with potential implications extending beyond cardiovascular diseases. Published by Elsevier Science Inc.