The Anxiolytic Effects of the 5-Hydroxytryptamine-1A Agonist Tandospirone Before Otolaryngologic Surgery
The Anxiolytic Effects of the 5-Hydroxytryptamine-1A Agonist Tandospirone Before Otolaryngologic Surgery
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5-羟色胺-1A激动剂坦度螺酮在耳鼻喉科手术前的抗焦虑作用
DOI：
10.1097/00000539-200111000-00034
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发表时间：
2001
影响因子：
5.7
通讯作者：
S. Dohi
中科院分区：
文献类型：
--
作者：
T. Oshima;Yoshiko Kasuya;E. Terazawa;K. Nagase;Y. Saitoh;S. Dohi
我们研究了160例阿萨I或II级择期耳鼻喉科手术患者，以比较新型5-羟色胺-1A激动剂坦度螺酮与地西泮的抗焦虑作用。为了监测术前焦虑，使用了以下变量：收缩压和舒张压、心率和由Spielberger状态-特质焦虑量表产生的状态焦虑评分。我们在手术前一天进行了治疗前评估，并在进入手术室后立即进行了治疗后检查。在双盲、随机设计中，4组40名患者在进入手术室前90分钟接受以下口服药物之一：1）坦度螺酮10 mg（T10组）; 2）坦度螺酮30 mg（T30组）; 3）地西泮10 mg（D组）;或4）安慰剂（P组）。T10组、T30组和D组术前状态焦虑均较术前降低（P <0.02），P组术前状态焦虑较术前升高（P <0.001）。坦度螺酮，10和30毫克，安全地减少术前焦虑的程度类似于口服地西泮10毫克在择期耳鼻喉科手术的患者。
We studied 160 ASA I or II patients undergoing elective otolaryngologic surgery in order to compare the anxiolytic effects of a novel 5-hydroxytryptamine-1A agonist, tandospirone, with diazepam. To monitor preoperative anxiety, the following variables were used: systolic and diastolic arterial pressure, heart rate, and the state anxiety score yielded by the Spielberger State-Trait Anxiety Inventory. We performed pretreatment evaluation on the day before surgery and posttreatment examination immediately after entry into the operating room. In a double-blinded, randomized design, four groups of 40 patients each received one of the following oral medications 90 min before entry into the operating room: 1) tandospirone 10 mg (T10 group); 2) tandospirone 30 mg (T30 group); 3) diazepam 10 mg (D group); or 4) placebo (P group). After premedication, the State-Trait Anxiety Inventory state anxiety decreased in the T10 (P < 0.02), T30 (P < 0.02), and D groups (P < 0.001), but it increased in the P group (P < 0.001). Tandospirone, 10 and 30 mg, safely reduced preoperative anxiety to a similar extent as oral diazepam 10 mg in patients undergoing elective otolaryngologic surgery.