QUANTITATIVE DESCRIPTION OF CLASSIC AND VARIANT SMALL CELL LUNG-CANCER CELL-LINES BY NUCLEAR IMAGE CYTOMETRY
QUANTITATIVE DESCRIPTION OF CLASSIC AND VARIANT SMALL CELL LUNG-CANCER CELL-LINES BY NUCLEAR IMAGE CYTOMETRY
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DOI：
10.1002/cyto.990090504
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发表时间：
1988-09-01
期刊：
影响因子：
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通讯作者：
VOOIJS, GP
中科院分区：
文献类型：
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作者：
BROERS, JLV;PAHLPLATZ, MMM;VOOIJS, GP
应用核图像分析技术对6个小细胞肺癌细胞系进行了检测，以寻找典型和变异型小细胞肺癌的特征。根据它们的生物化学和生物学特性，这些细胞系中的三个已被证明呈现经典类型，并且三个代表SCLC的变体类型。使用图像衍生的游程长度、密度和几何特征的组合，可以区分经典和变异SCLC细胞系。本研究的结果可能有助于评估光度特征，用于分离实体瘤中SCLC的经典亚型和变异亚型。由于这两种亚型在治疗和预后方面的差异，这种分离可能具有临床价值。
Six small cell lung cancer (SCLC) cell lines were examined using nuclear image analysis to find features characteristic of the classic and the variant type of SCLC. On the basis of their biochemical and biological propreties three of these cells lines have been shown to present the classic types, and three represent the variant type of SCLC. Using a combination of the immage-derived run length, densitiy, and geometric features, it was possible to distinguish between the classic and variant SCLC cell lines. The results of this study may be of help in assessing photometric features for the separation of the classic and variant subtypes of SCLC in solid tumors. Because of differences in treatment and prognosis between these two subtypes, such a separation may be clinical value.