Physical activity and weight gain after smoking cessation in postmenopausal women.
Physical activity and weight gain after smoking cessation in postmenopausal women.
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DOI：
10.1097/gme.0000000000001168
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发表时间：
2019-01
期刊：
影响因子：
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通讯作者：
Margolis KL
中科院分区：
文献类型：
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作者：
Luo J;Manson JE;Hendryx M;Shadyab AH;Johnson KC;Dinh PC Jr;Going SB;Chlebowski R;Stefanick ML;Margolis KL
体重增加经常发生在戒烟后。本研究的目的是检查绝经后妇女戒烟后体重增加是否被PA减弱。研究人员对来自妇女健康倡议（WHI）的4717名基线吸烟者进行了为期三年的随访。1282名女性戒烟，3435名女性继续吸烟。在基线和第3年访视时测量体重。在两个时间点通过自我报告评估PA，总结为代谢当量任务（MET）-每周小时。多元线性回归模型用于评估PA和戒烟后体重增加之间的关联，调整潜在的混杂因素。与持续吸烟者相比，戒烟者在基线和第3年访视之间平均增加了3.5 kg（SD=5.6）。PA降低的戒烟者体重增加量最高（3.88 kg，95% CI：3.22-4.54）; PA增加（≥15 MET-小时/周）的戒烟者体重增加量最低（2.55 kg，95% CI：1.59-3.52）。与正常体重的女性相比，增加PA对肥胖女性戒烟后体重增加有更强的有益关联。与持续吸烟者相比，在基线时PA低而在第3年PA高且也参加饮食调整干预的戒烟者体重增加不显著（1.88 kg，95% CI：-0.21-3.96）。我们的数据表明，即使是适度增加PA（相当于目前的建议）也可以减轻绝经后妇女戒烟后的体重增加，特别是与改善饮食相结合。
Weight gain frequently occurs following smoking cessation. The objective of this study was to examine whether weight gain after smoking cessation was attenuated by PA in postmenopausal women. 4717 baseline smokers from the Women’s Health Initiative (WHI) were followed for three years. 1282 women quit smoking, and 3435 continued smoking. Weight was measured at baseline and at the year 3 visit. PA was assessed at both times by self-report, summarized as metabolic equivalent task (MET)-hours per week. Multiple linear regression models were used to assess the association between PA and post-cessation weight gain, adjusting for potential confounding factors. Compared with continuing smokers, quitters gained an average of 3.5 kg (SD=5.6) between the baseline and year 3 visit. Quitters with decreased PA had the highest amount of weight gain (3.88 kg, 95% CI: 3.22-4.54); quitters with increased PA (≥15 MET-hours/week) had the lowest weight gain (2.55 kg, 95% CI: 1.59-3.52). Increased PA had a stronger beneficial association for post-cessation weight gain for obese women compared to normal weight women. Quitters who had low PA at baseline and high PA at year 3 and were also enrolled in a dietary modification intervention had non-significant weight gain (1.88 kg, 95% CI: −0.21-3.96) compared with continuing smokers. Our data demonstrate that even a modest increase in PA (equivalent to current recommendations) can attenuate weight gain after quitting smoking among postmenopausal women, especially in combination with improved diet.