Development of a Pediatric Ebola Predictive Score, Sierra Leone(1).
Development of a Pediatric Ebola Predictive Score, Sierra Leone(1).
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小儿埃博拉病毒预测评分的发展，塞拉利昂（1）。
DOI：
10.3201/eid2402.171018
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发表时间：
2018-03
影响因子：
11.8
通讯作者：
Yeung S
中科院分区：
文献类型：
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作者：
Fitzgerald F;Wing K;Naveed A;Gbessay M;Ross JCG;Checchi F;Youkee D;Jalloh MB;Baion DE;Mustapha A;Jah H;Lako S;Oza S;Boufkhed S;Feury R;Bielicki J;Williamson E;Gibb DM;Klein N;Sahr F;Yeung S
我们将埃博拉病毒病 (EVD) 阳性儿童与阴性儿童进行比较，得出儿科 EVD 预测因子 (PEP) 评分。我们收集了 2014 年 8 月至 2015 年 3 月期间塞拉利昂 11 个埃博拉收容所收治的所有 <13 岁儿童的数据，并进行了多变量逻辑回归。在 1,054 名儿童中，309 名（29%）埃博拉病毒病阳性，697 名（66%）埃博拉病毒病阴性，还有 48 名（5%）缺失。接触史、结膜炎和年龄是埃博拉病毒病最强的阳性预测因素。 PEP 评分的受试者工作特征曲线下面积为 0.80。 PEP 评分为 7/10 时特异性为 92%，敏感性为 44%； 3/10 的特异性为 30%，敏感性为 94%。 PEP 评分可以正确分类 79%–90% 的儿童，并可用于根据所需的敏感性或特异性对风险类别进行分类。
We compared children who were positive for Ebola virus disease (EVD) with those who were negative to derive a pediatric EVD predictor (PEP) score. We collected data on all children <13 years of age admitted to 11 Ebola holding units in Sierra Leone during August 2014–March 2015 and performed multivariable logistic regression. Among 1,054 children, 309 (29%) were EVD positive and 697 (66%) EVD negative, with 48 (5%) missing. Contact history, conjunctivitis, and age were the strongest positive predictors for EVD. The PEP score had an area under receiver operating characteristics curve of 0.80. A PEP score of 7/10 was 92% specific and 44% sensitive; 3/10 was 30% specific, 94% sensitive. The PEP score could correctly classify 79%–90% of children and could be used to facilitate triage into risk categories, depending on the sensitivity or specificity required.
DOI：
10.1093/cid/cix223
发表时间：
2017-07-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Fitzgerald F;Wing K;Naveed A;Gbessay M;Ross JCG;Checchi F;Youkee D;Jalloh MB;Baion D;Mustapha A;Jah H;Lako S;Oza S;Boufkhed S;Feury R;Bielicki J;Williamson E;Gibb DM;Klein N;Sahr F;Yeung S
通讯作者：
Yeung S