The elephant in the room: do microRNA-based therapies have a realistic chance of succeeding for brain tumors such as glioblastoma?
The elephant in the room: do microRNA-based therapies have a realistic chance of succeeding for brain tumors such as glioblastoma?
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DOI：
10.1007/s11060-010-0449-5
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发表时间：
2011-07
影响因子：
3.9
通讯作者：
Purow, Benjamin
中科院分区：
文献类型：
--
作者：
Purow, Benjamin
很明显，microRNAs在神经肿瘤学中扮演着重要的角色，就像它们在生物学的所有领域一样。随着在组织和血清中检测和定量microrna的最新进展，microrna作为脑肿瘤和其他癌症的生物标志物在临床上越来越有可能发挥作用。然而，到目前为止，应用microrna治疗脑肿瘤面临着更大的障碍，尽管体外结果很有希望，但这可能永远不会成为现实。这篇综述将最近的进展纳入考虑microrna在脑肿瘤治疗中的潜力的框架，考虑到单个microrna的力量、递送问题和间接的基于microrna的治疗。
It seems quite clear that microRNAs play important roles in neuro-oncology, as they do across perhaps all areas in biology. With recent advances in detecting and quantifying microRNAs in tissue and serum, it appears increasingly likely that microRNAs will be clinically useful as biomarkers for brain tumors and other cancers. Applying microRNAs for treatment of brain tumors poses greater hurdles by far, however, and despite promising in vitro results this may never become a reality. This review fits recent advances into a framework for considering the potential of microRNAs for brain tumor therapy, considering the power of individual microRNAs, delivery issues, and indirect microRNA-based therapies.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
DOI：
10.4161/cc.9.6.10987
发表时间：
2010-03-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
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作者：
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作者：
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通讯作者：
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