Dose-response relationship between intensity of exercise and cognitive performance in individuals with Down syndrome: a preliminary study
Dose-response relationship between intensity of exercise and cognitive performance in individuals with Down syndrome: a preliminary study
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DOI：
10.1111/jir.12258
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发表时间：
2016-06-01
影响因子：
3.6
通讯作者：
Ringenbach, S. D. R.
中科院分区：
文献类型：
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作者：
Chen, C. -C. (J. J. );Ringenbach, S. D. R.
认知表现已被证明与唐氏综合症患者阿尔茨海默病的早期发病有关。本研究旨在调查该人群急性运动强度与认知能力之间的剂量-反应关系。方法在本研究中，我们测量了信息处理速度和两个方面的执行功能（即注意转移和抑制控制）。参与者被分配到高强度运动（即预测最大心率的75-85%）（N=6）、中等强度运动（即预测最大心率的50-75%）（N=6）或注意力控制（N=6）组。两个运动组在跑步机上使用增量强度步行协议行走，而注意力控制组观看20分钟的视频。在干预前和干预后测试信息处理速度和执行功能。结果在高强度运动中，学生的选择反应时间测试成绩下降，而在中等强度运动中，学生的选择反应时间测试成绩有所提高。然而，中等强度和高强度运动对执行功能的抑制控制方面是有益的。此外，与以往研究不同的是，信息处理速度呈二次曲线趋势，抑制控制呈线性趋势。结论未来的研究需要更大的样本量进行检验，需要更多的生理测量来探索运动强度与唐氏综合征个体认知表现之间关系的潜在机制。
Background Cognitive performance has been shown to be relevant to the early onset of Alzheimer's disease in individuals with Down syndrome. This study was aimed at investigating the dose-response relationship between acute exercise intensity and cognitive performance in this population.Methods In the current study, we measured information processing speed and two aspects of executive function (i.e. attention shifting and inhibitory control). Participants were assigned to high-intensity exercise (i.e. 75-85% of predicted maximum heart rate) (N=6), moderate-intensity exercise (i.e. 50-75% of predicted maximum heart rate) (N= 6) or attentional control (N= 6) groups. Two exercise groups walked on a treadmill using an incremental intensity walking protocol, and the attentional control group watched a video for 20 min. Measures of information processing speed and executive function were tested pre-intervention and post-intervention.Results Our results indicated that the performance in choice reaction time test was impaired in the high-intensity exercise, whereas improved performance was observed in the moderate-intensity exercise. However, moderate-intensity and high-intensity exercises were beneficial for inhibitory control aspect of executive function. Further, inconsistent with previous studies, a quadric trend was seen in information processing speed, and a liner trend was evident in inhibitory control.Conclusions Future research is needed to examine with a larger sample size, and more physiological measures are necessary to explore the underlying mechanisms in the relationship between exercise intensity and cognitive performance in individuals with Down syndrome.