Consistently high estimates for the proportion of human exposure to malaria vector populations occurring indoors in rural Africa
Consistently high estimates for the proportion of human exposure to malaria vector populations occurring indoors in rural Africa
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DOI：
10.1093/ije/dys214
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发表时间：
2013-02-01
影响因子：
7.7
通讯作者：
Killeen, Gerry
中科院分区：
文献类型：
--
作者：
Huho, Bernadette;Briet, Olivier;Killeen, Gerry
在非洲，驱虫蚊帐（ITNs）和室内滞留喷洒（IRS）是控制疟疾传播的非常有效的工具，因为最重要的媒介，冈比亚按蚊复合体和冈比亚按蚊是非洲最重要的媒介。funestus组，通常喜欢咬人类在室内night.Methods匹配调查的蚊子和人类的行为，从6个农村网站在布基纳法索，坦桑尼亚，赞比亚和肯尼亚，ITN的使用范围从0.2%到82.5%，被用来计算的比例，人类暴露于An。gambiae sensu lato和An.富内斯图斯公司这是室内病媒控制措施所能提供的个人保护上限的一个指标。还通过使用简化的二元分析（pi（B）（i））来估计该数量，使得室内捕获的蚊子的比例（P-i）以及大多数人在室内的第一个小时和最后一个小时之间的蚊子的比例（P-fl）也可以计算为室内或夜间蚊子进食的基本指标，结果绝大多数人接触按蚊叮咬发生在室内（pi（B）（i）= 0.79-1.00）。也不是安。冈比亚有限公司也不是安富内斯图斯公司强烈偏好室内饲养（P-i分别为0.40-0.63和0.22-0.69），但它们绝大多数都喜欢在大多数人都在室内的时候进食。（P-fl = 0.78-1.00和0.86-1.00，）结论这些对人类和蚊子之间的行为相互作用的定量总结构成了一个非常一致的基准，可以比较矢量行为的观察结果。对这些数量的纵向监测对于评价驱虫蚊帐和室内滞留喷洒的有效性以及是否需要采取针对户外病媒的补充措施至关重要。
Background Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are highly effective tools for controlling malaria transmission in Africa because the most important vectors, from the Anopheles gambiae complex and the A. funestus group, usually prefer biting humans indoors at night.Methods Matched surveys of mosquito and human behaviour from six rural sites in Burkina Faso, Tanzania, Zambia, and Kenya, with ITN use ranging from 0.2% to 82.5%, were used to calculate the proportion of human exposure to An. gambiae sensu lato and An. funestus s.l. that occurs indoors (pi(i)), as an indicator of the upper limit of personal protection that indoor vector control measures can provide. This quantity was also estimated through use of a simplified binary analysis (pi(B)(i)) so that the proportions of mosquitoes caught indoors (P-i), and between the first and last hours at which most people are indoors (P-fl) could also be calculated as underlying indicators of feeding by mosquitoes indoors or at night, respectively.Results The vast majority of human exposure to Anopheles bites occurred indoors (pi(B)(i) = 0.79-1.00). Neither An. gambiae s.l. nor An. funestus s.l. strongly preferred feeding indoors (P-i = 0.40-0.63 and 0.22-0.69, respectively), but they overwhelmingly preferred feeding at times when most humans were indoors (P-fl = 0.78-1.00 and 0.86-1.00, respectively).Conclusions These quantitative summaries of behavioural interactions between humans and mosquitoes constitute a remarkably consistent benchmark with which future observations of vector behaviour can be compared. Longitudinal monitoring of these quantities is vital to evaluate the effectiveness of ITNs and IRS and the need for complementary measures that target vectors outdoors.