Prenatal origins of individual variation in behavior and immunity
Prenatal origins of individual variation in behavior and immunity
复制标题
DOI：
10.1016/j.neubiorev.2004.11.003
复制
发表时间：
2005-02-01
影响因子：
8.2
通讯作者：
Lubach, GR
中科院分区：
文献类型：
--
作者：
Coe, CL;Lubach, GR
子宫内环境在启动许多生理系统的正常个体发育中起着至关重要的作用。因此，产前生活中的干扰会影响婴儿的成熟轨迹，有时还会导致影响产后健康的慢性变化。我们的综述总结了支持这些结论的一系列恒河猴研究。对怀孕雌性垂体-肾上腺轴的心理障碍或药物刺激会影响婴儿的神经发育：猴子在出生时表现出不成熟的神经运动反射，在生命的第一年表现出更大的情绪，并且在青少年时期表现出较小的海马体。婴儿的免疫反应也受到影响：淋巴细胞增殖、自然杀伤活性和细胞因子产生减少。涉及多种介导途径，包括激素和营养物质的胎盘转移，以及幼猴对饲养环境的差异反应。例如，胃肠道中有益微生物群落的建立显着减少，这与肠道感染的更大风险相关。这些发现表明，胎儿时期的事件可能会持续影响出生后的生理机能，并使平衡从健康转向疾病。 (C) 2004 Elsevier Ltd. 保留所有权利。
The in utero environment plays a critical role in initiating the normal ontogeny of many physiological systems. As a consequence, disturbances during prenatal life can affect the baby's maturational trajectory and sometimes cause chronic alterations that influence health postpartum. Our review summarizes a series of studies in rhesus monkeys supporting these conclusions. Psychological disturbance or pharmacological stimulation of the gravid female's pituitary-adrenal axis affected the infant's neurological development: monkeys evinced immature neuromotor reflexes at birth, greater emotionality during the first year of life, and a smaller hippocampus as juveniles. Immune responses of the infants were also affected: lymphocyte proliferation, natural killer activity and cytokine production were reduced. Several mediating pathways were implicated, including the placental transfer of hormones and nutrients, and a differential response of the infant monkey to the rearing environment. For example, the establishment of beneficial types of microflora in the gastrointestinal tract was significantly reduced, which was associated with a greater risk for enteric infection. These findings indicate that events during fetal life can persistently influence physiology after birth and tilt the balance away from health and toward illness. (C) 2004 Elsevier Ltd. All rights reserved.