Apoptosis in inner ear sensory hair cells.
Apoptosis in inner ear sensory hair cells.
复制标题
内耳感觉毛细胞的凋亡。
DOI：
10.1016/j.joto.2017.08.001
复制
发表时间：
2017-12
影响因子：
1.9
通讯作者：
He DZZ
中科院分区：
文献类型：
--
作者：
Morrill S;He DZZ
细胞凋亡，或受控细胞死亡，是细胞寿命的正常部分。耳蜗毛细胞的细胞死亡会导致耳聋；这是一种尚不清楚的细胞凋亡过程。在全球范围内，13亿人遭受某种形式的听力损失，而3.6亿人遭受衰弱听力损失的直接原因是这些耳蜗毛细胞的缺乏。由于20世纪中期以来所做的研究，人们对其他系统和其他细胞类型中的细胞凋亡有了很多了解。在这里，我们综述了当前关于细胞凋亡的文献，以及细胞凋亡导致耳聋和耳蜗毛细胞丢失的原因。B细胞淋巴瘤(B细胞淋巴瘤)蛋白家族是研究和表征最多的蛋白之一。我们将回顾目前文献中关于Bcl2和Bcl6蛋白相互作用与细胞凋亡的关系，以及它们在耳蜗毛细胞的脆弱性和生存中的可能作用。
Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells. Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl) proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells.