Phylodynamic analyses of class I Newcastle disease virus isolated in China
Phylodynamic analyses of class I Newcastle disease virus isolated in China
复制标题
中国分离的I类新城疫病毒的系统动力学分析
DOI：
10.1111/tbed.13785
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发表时间：
2020-08-20
影响因子：
4.3
通讯作者：
Xiang, Bin
中科院分区：
文献类型：
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作者：
Chen, Libin;Song, Jie;Xiang, Bin
纽卡斯尔病病毒（NDV）是纽卡斯尔病的病原，给世界范围内的养禽业造成了重大损失。然而，由于其无毒性，I类NDV没有像II类NDV那样多地被研究。我们的目的是流行病学监测I类NDV在中国的传播。我们在2016年1月至2018年12月期间从中国南方广东省活禽市场（LPMs）的家禽中分离了104株I类NDV毒株。遗传分析表明，所有104个分离物和大部分来自中国的分离物聚为I类NDV基因型1.1.2。贝叶斯分析表明，虽然美国可能是来源，但中国东部和南部可能是中国I类NDV的震中。此外，在中国，I类NDV可能由鸡和家鸭传播，因为病毒主要在这些鸟类中流行。这些新的发现表明，I类NDV在中国南方流行，重要的是要进行常规监测，并限制不同鸟类在不同地区的LPM的数量，以降低NDV的种内和种间传播的风险。
Newcastle disease virus (NDV), the pathogen of Newcastle disease, has caused significant losses to the poultry industry worldwide. However, owing to its avirulence, class I NDVs have not been studied as much as class II NDVs. We aimed to epidemiologically monitor the spread of class I NDVs in China. We isolated 104 class I NDV strains from poultry in live poultry markets (LPMs) of Guangdong Province, south China, between January 2016 and December 2018. Genetic analysis revealed that all 104 isolates and most of the strains isolated from China were clustered into genotype 1.1.2 of class I NDVs. Bayesian analysis revealed that, although the United States may be the source, east and south China may be the epicentres of class I NDVs in China. In addition, in China, class I NDVs are presumably transmitted by chickens and domestic ducks as the virus is mostly prevalent in these birds. These novel findings demonstrated that class I NDVs are prevalent in south China, and it is important to perform routine surveillance and limit the numbers of different birds in different areas of LPMs to decrease the risk of intra- and interspecies transmission of NDVs.