Prediction of malignant potential in reflux disease: Are cytokine polymorphisms important?
Prediction of malignant potential in reflux disease: Are cytokine polymorphisms important?
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DOI：
10.1111/j.1572-0241.2005.40904.x
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发表时间：
2005-05-01
影响因子：
9.8
通讯作者：
Bird, NC
中科院分区：
文献类型：
--
作者：
Gough, MD;Ackroyd, R;Bird, NC
目的：食管反流在西方世界很常见，并可导致许多疾病，如食管炎、巴雷特食管和腺癌。Barrett's易患腺癌，内镜监测可能导致腺癌的早期发现。然而，临床方法仅在15名患者中识别出1名Barrett食管患者。本研究的目的是寻找因素，可能有助于确定患者与Barrett's earlier.METHODS：血液样本和详细的历史，从456例胃食管反流谁被招募到三个研究组：食管炎，Barrett's食管无异型增生，和Barrett's异型增生或腺癌。PCR用于确定五种功能性细胞因子多态性的频率：白细胞介素-1受体拮抗剂位置+2018（IL-1 Ra +2018），白细胞介素-1 β位置-511（IL-1 β-511），肿瘤坏死因子-α位置-238（TNF-α-238），白细胞介素-10位置+1082（IL-10 + 1082）和白细胞介素-4受体位置-1902结果：IL-1 Ra +2018基因型2/2与Barrett's的相关性高于食管炎（OR-3.7，p = 0.0345）。IL-10 + 1082基因型2/2与Barrett's和腺癌的相关性比食管炎更强（分别为OR-1.76，p = 0.056和OR 1.96，p = 0.025）。IL-1 β-511，IL-4 R-1902和TNF-α-238多态性没有差异。结论：细胞因子多态性在Barrett's或腺癌患者中比食管炎患者更常见。结合人口统计学数据，这可能有助于识别那些从监测中受益的巴雷特患者。
OBJECTIVES: Esophageal reflux is common in the Western world and can lead to a number of diseases, such as esophagitis, Barrett's esophagus, and adenocarcinoma. Barrett's predisposes to adenocarcinoma and endoscopic surveillance may lead to earlier detection of adenocarcinoma. However, clinical methods only identify one patient in 15 with Barrett's esophagus. The aim of this study was to find factors that may help identify patients with Barrett's earlier.METHODS: Blood samples and detailed histories were taken from 456 patients with gastroesophageal reflux who were recruited into three study groups: esophagitis, Barrett's esophagus without dysplasia, and Barrett's with dysplasia or adenocarcinoma. PCR was used to determine the frequency of five functional cytokine polymorphisms: interleukin-1 receptor antagonist position +2018 (IL-1 Ra +2018), interleukin-1 beta position -511 (IL-1 beta-511), tumor necrosis factor-alpha position -238 (TNF-alpha -238), interleukin-10 position +1082 (IL-10 +1082), and interleukin-4 receptor position -1902 (IL-4R -1902).RESULTS: IL-1 Ra +2018 genotype 2/2 was associated with Barrett's more commonly than esophagitis (OR-3.7, p = 0.0345). The IL-10 +1082 genotype 2/2 was more strongly associated with Barrett's and adenocarcinoma than esophagitis (OR-1.76, p = 0.056 and OR 1.96, p = 0.025, respectively). There were no differences for the IL-1 beta -511, IL-4R -1902, and TNF-alpha -238 polymorphisms.CONCLUSIONS: Cytokine polymorphisms are more commonly found in patients with Barrett's or adenocarcinoma than those with esophagitis. Together with demographic data, this may help identify those patients with Barrett's who would benefit from surveillance.