Keratinocytes under Fire of Proinflammatory Cytokines: Bona Fide Innate Immune Cells Involved in the Physiopathology of Chronic Atopic Dermatitis and Psoriasis.
Keratinocytes under Fire of Proinflammatory Cytokines: Bona Fide Innate Immune Cells Involved in the Physiopathology of Chronic Atopic Dermatitis and Psoriasis.
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DOI：
10.1155/2012/718725
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Lecron JC
中科院分区：
文献类型：
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作者：
Bernard FX;Morel F;Camus M;Pedretti N;Barrault C;Garnier J;Lecron JC
皮肤的稳态和防御是通过特定表皮角质形成细胞和驻留或募集在皮肤中的免疫细胞之间的永久相互作用，通过产生细胞因子来维持的。如果需要，一个协调的炎症反应被触发，由特定的细胞因子传递。由于种种原因，这种现象的解决困难会产生细胞因子介导的恶性循环，促进皮肤慢性炎症，最常见的是特应性皮炎和牛皮癣。在本文中，我们讨论了细胞因子对角质形成细胞的生物学作用，特别是在特应性皮炎或牛皮癣中涉及的特异性或共享细胞因子。我们报道并讨论了单层或三维的角质细胞体外模型，通过特定的细胞因子刺激来模拟特应性皮炎或牛皮癣。IL-22、TNFa、IL-4和IL-13的组合能够模拟“特应性皮炎样”状态。银屑病皮损中IL-17过表达，IL-4和IL-13未检出；这种混合物中的IL-17替代IL-4和IL-13能够在体外模拟角质形成细胞的“牛皮癣样”状态。我们的结论是，特定的细胞因子环境调节在皮肤形态和先天免疫中起着核心作用，朝着特定的病理方向发展，并为新的治疗策略开辟了道路。
Cutaneous homeostasis and defenses are maintained by permanent cross-talk among particular epidermal keratinocytes and immune cells residing or recruited in the skin, through the production of cytokines. If required, a coordinated inflammatory response is triggered, relayed by specific cytokines. Due to numerous reasons, troubles in the resolution of this phenomenon could generate a cytokine-mediated vicious circle, promoting skin chronic inflammation, the most common being atopic dermatitis and psoriasis. In this paper, we discuss the biological effects of cytokine on keratinocytes, more particularly on specific or shared cytokines involved in atopic dermatitis or psoriasis. We report and discuss monolayer or 3D in vitro models of keratinocytes stimulated by specific sets of cytokines to mimic atopic dermatitis or psoriasis. IL-22, TNFa, IL-4, and IL-13 combination is able to mimic an “atopic dermatitis like” state. In psoriasis lesions, over expression of IL-17 is observed whereas IL-4 and IL-13 were not detected; the replacement of IL-4 and IL-13 by IL-17 from this mix is able to mimic in vitro a “psoriasis like” status on keratinocytes. We conclude that specific cytokine environment deregulation plays a central role on skin morphology and innate immunity, moving towards specific pathologies and opening the way to new therapeutic strategies.