Two is More Than One: How to Combine Brain Stimulation Rehabilitative Training for Functional Recovery?
Two is More Than One: How to Combine Brain Stimulation Rehabilitative Training for Functional Recovery?
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两个不止一个：如何结合大脑刺激康复训练以进行功能恢复？
DOI：
10.3389/fnsys.2015.00154
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发表时间：
2015
影响因子：
3
通讯作者：
Mima T
中科院分区：
文献类型：
--
作者：
Koganemaru S;Fukuyama H;Mima T
多项研究表明，非侵入性脑刺激与康复疗法相结合，比单独使用任何一种疗法都有额外的促进功能恢复的效果。这种组合增强了重复训练所诱导的依赖使用的可塑性。这种联合作用的神经生理机制是基于联想可塑性的。然而，这些影响并不是在所有情况下都有报道。我们提出了一系列可能的策略，以实现康复训练与可塑性大脑刺激之间的有效联系：(1)控制刺激和任务执行之间的时间方面；(2)组合使用成形的任务；(3)适当刺激发生使用依赖可塑性变化的神经元回路；以及(4)有节奏的脑刺激和与任务相关的神经元模式活动之间的阶段同步。为了更好地利用脑刺激进行神经康复，开发更有效的技术将两者结合起来是很重要的。
A number of studies have shown that non-invasive brain stimulation has an additional effect in combination with rehabilitative therapy to enhance functional recovery than either therapy alone. The combination enhances use-dependent plasticity induced by repetitive training. The neurophysiological mechanism of the effects of this combination is based on associative plasticity. However, these effects were not reported in all cases. We propose a list of possible strategies to achieve an effective association between rehabilitative training with brain stimulation for plasticity: (1) control of temporal aspect between stimulation and task execution; (2) the use of a shaped task for the combination; (3) the appropriate stimulation of neuronal circuits where use-dependent plastic changes occur; and (4) phase synchronization between rhythmically patterned brain stimulation and task-related patterned activities of neurons. To better utilize brain stimulation in neuro-rehabilitation, it is important to develop more effective techniques to combine them.