DNA and RNA derivatives to optimize distribution and delivery.
DNA and RNA derivatives to optimize distribution and delivery.
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DOI：
10.1016/j.addr.2015.04.012
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发表时间：
2015-06-29
影响因子：
16.1
通讯作者：
Wickstrom E
中科院分区：
文献类型：
--
作者：
Wickstrom E
人工合成的互补DNA单链和短干扰RNA双链已被发现以剂量依赖和序列特异性的方式抑制动物、植物和病毒基因在细胞、动物和患者中的表达。然而，DNA和RNA在生物系统中很容易被消化。因此，化学家有义务设计和合成正常DNA的抗核酸酶类似物(图1)。
Synthetic, complementary DNA single strands and short interfering RNA double strands have been found to inhibit the expression of animal, plant, and viral genes in cells, animals, and patients, in a dose dependent and sequence specific manner. DNAs and RNAs, however, are readily digested in biological systems. Hence, chemists are obliged to design and synthesize nuclease-resistant analogs of normal DNA (Fig. 1).