Identification of persons at high risk for kidney disease via targeted screening: The NKF Kidney Early Evaluation Program
Identification of persons at high risk for kidney disease via targeted screening: The NKF Kidney Early Evaluation Program
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DOI：
10.1046/j.1523-1755.63.s83.11.x
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发表时间：
2003-02-01
影响因子：
19.6
通讯作者：
Keane, WF
中科院分区：
文献类型：
--
作者：
Brown, WW;Collins, A;Keane, WF
背景。 1999 年底，美国有超过 340,000 人正在接受肾脏替代治疗；预计到 2010 年，这一数字将增加一倍。几乎一半的人初步诊断为糖尿病，特别是 2 型糖尿病，超过四分之一的人初步诊断为高血压。研究表明，有效的措施可以预防或延缓肾脏疾病的进展速度，并降低发病率和死亡率。早期诊断的目的是在干预有合理潜力对结果产生积极影响时及早发现无症状疾病。方法。 1997 年，国家肾脏基金会启动了 KEEP(TM)（肾脏早期评估计划），这是一项基于社区的免费筛查，针对患有高血压、糖尿病或肾脏疾病的患者以及有糖尿病或高血压个人病史的患者的一级亲属。结果。在试点研究中筛查的 889 人中，71.4% 的人至少有一种异常。该计划包括教育部分和转介给医生以跟踪异常值。结论。有针对性的筛查是识别有肾脏疾病风险的人的有效手段，并且可以在疾病过程中及早识别有风险的人，以便进行有效干预。
Background. More than 340,000 individuals were receiving renal replacement therapy in the United States at the end of 1999; this number is projected to double by the year 2010. Almost half had a primary diagnosis of diabetes mellitus particularly type 2, and more than one quarter a primary diagnosis of hypertension. Studies have demonstrated effective maneuvers to prevent or delay the rate of progression of kidney disease, and decrease morbidity and mortality. The objective of early diagnosis is early detection of asymptomatic disease at a time when intervention has a reasonable potential to have a positive impact on outcome.Methods. In 1997, the National Kidney Foundation launched KEEP(TM) (Kidney Early Evaluation Program), a free community-based screening that targets first order relatives of persons with hypertension, diabetes or kidney disease, and those with a personal history of diabetes or hypertension.Results. Of the 889 individuals screened in the pilot study, 71.4% had at least one abnormality. The program includes an educational component and referral to a physician for follow-up of abnormal values.Conclusions. Targeted screenings are an effective means of identifying persons at risk for kidney disease, and can identify individuals at risk early enough in the course of their disease to allow for effective intervention.