Predictive Effects of Inflammatory Scores in Patients with BCLC 0-A Hepatocellular Carcinoma after Hepatectomy
Predictive Effects of Inflammatory Scores in Patients with BCLC 0-A Hepatocellular Carcinoma after Hepatectomy
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DOI：
10.3390/jcm8101676
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发表时间：
2019-10-01
影响因子：
3.9
通讯作者：
Tsai, Ming-Chao
中科院分区：
文献类型：
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作者：
Huang, Pao-Yuan;Wang, Chih-Chi;Tsai, Ming-Chao
背景：炎症标志物被认为是肝细胞癌（HCC）预后的预后因素。示例包括嗜中性粒细胞与淋巴细胞比率（NLR）;血小板与淋巴细胞比率（PLR）;预后营养指数（PNI）中使用的白蛋白和淋巴细胞计数;以及全身免疫炎症指数（SII）中使用的嗜中性粒细胞、淋巴细胞和血小板计数。本研究评估了PNI、NLR、PLR和SII对预测巴塞罗那临床肝癌（BCLC）0-A期HCC患者肝切除术后复发和生存的影响。方法：本回顾性研究在台湾高雄中庚纪念医院进行。该研究入组了891例在2001年至2016年期间接受肝切除术的BCLC 0/A期HCC患者（77.9%为男性;平均年龄58.53 ± 11.60岁）。术前测定PNI、NLR、PLR和SII。结果：高NLR（> 1.8）与总生存率呈负相关（p = 0.032）。低PNI（
Background: Inflammatory markers are regarded as prognostic factors of the outcomes of hepatocellular carcinoma (HCC). Examples include the neutrophil-to-lymphocyte ratio (NLR); platelet to lymphocyte ratio (PLR); the albumin and lymphocyte counts used in the prognostic nutritional index (PNI); and the neutrophil, lymphocyte, and platelet counts used in the systemic immune-inflammation index (SII). This study evaluates the effects of PNI, NLR, PLR, and SII to predict recurrence and survival in patients with Barcelona Clinic Liver Cancer (BCLC) stages 0-A of HCC after hepatectomy. Methods: This retrospective study was conducted at Kaohsiung Chung-Gung Memorial Hospital, Taiwan. The study enrolled 891 patients (77.9% males; mean age 58.53 +/- 11.60 years) with BCLC stage 0/A HCC undergoing hepatectomy between 2001 and 2016. PNI, NLR, PLR and SII were measured before hepatectomy. Results: High NLR (>1.8) was adversely associated with overall survival (p = 0.032). Low PNI (