High frequency oscillations in intra- operative electrocorticography before and after epilepsy surgery
High frequency oscillations in intra- operative electrocorticography before and after epilepsy surgery
复制标题
DOI：
10.1016/j.clinph.2014.03.004
复制
发表时间：
2014-11-01
影响因子：
4.7
通讯作者：
Zijlmans, M.
中科院分区：
文献类型：
--
作者：
van Klink, N. E. C.;van't Klooster, M. A.;Zijlmans, M.
目的：切除癫痫患者术前皮层脑电地形图(PreECoG)中出现高频振荡(HFO)的脑组织(波纹：80-250赫兹和快速波纹：250-500赫兹)似乎是良好手术结果的预测指标。方法：对14例患者术中2048赫兹的脑电地形图(ECoG)中1min时段的HFO进行自动检测。分析切除和未切除电极的波纹、快速波纹、尖峰、尖峰上的波纹(ROS)和不在尖峰上的波纹(RNOS)的比率。RNOs下降幅度小于ROS(74%vs.83%；p=0.01)。前ECoG的快波多位于切除的组织内。1例患者出现后快速涟漪，预后较差。预后良好的患者术后RNOS率相对较高，特别是在感觉运动皮质。结论：我们的观察表明，与波纹相比，术中ECoG中的快速波纹可能是更好的致痫生物标志物。进一步的研究需要确定癫痫组织切除与感觉运动皮质产生的生理性波纹的关系。意义：术中ECoG中的快速波纹有助于识别致痫区域，而波纹也可能是生理性的。(C)2014年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: Removal of brain tissue showing high frequency oscillations (HFOs; ripples: 80-250 Hz and fast ripples: 250-500 Hz) in preresection electrocorticography (preECoG) in epilepsy patients seems a predictor of good surgical outcome. We analyzed occurrence and localization of HFOs in intra-operative preECoG and postresection electrocorticography (postECoG).Methods: HFOs were automatically detected in one-minute epochs of intra-operative ECoG sampled at 2048 Hz of fourteen patients. Ripple, fast ripple, spike, ripples on a spike (RoS) and not on a spike (RnoS) rates were analyzed in pre- and postECoG for resected and nonresected electrodes.Results: Ripple, spike and fast ripple rates decreased after resection. RnoS decreased less than RoS (74% vs. 83%; p = 0.01). Most fast ripples in preECoG were located in resected tissue. PostECoG fast ripples occurred in one patient with poor outcome. Patients with good outcome had relatively high postECoG RnoS rates, specifically in the sensorimotor cortex.Conclusions: Our observations show that fast ripples in intra-operative ECoG, compared to ripples, may be a better biomarker for epileptogenicity. Further studies have to determine the relation between resection of epileptogenic tissue and physiological ripples generated by the sensorimotor cortex.Significance: Fast ripples in intra-operative ECoG can help identify the epileptogenic zone, while ripples might also be physiological. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights.