A novel, noninvasive assay shows that distal airway oxygen tension is low in cystic fibrosis, but not in primary ciliary dyskinesia.
A novel, noninvasive assay shows that distal airway oxygen tension is low in cystic fibrosis, but not in primary ciliary dyskinesia.
复制标题
一项新颖的无创检测表明，囊性纤维化患者的远端气道氧分压较低，但原发性纤毛运动障碍则不然。
DOI：
10.1002/ppul.24192
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发表时间：
2019
影响因子：
3.1
通讯作者：
Gaston,Benjamin
中科院分区：
文献类型：
--
作者：
Mendelsohn,Lori;Wijers,Christiaan;Gupta,Ritika;Marozkina,Nadzeya;Li,Chun;Gaston,Benjamin
目的氧张力影响需氧和厌氧生物的生物学。使用一种新型的快速响应传感器，我们开发了一种无创程序来测量人体远端气道中的pO 2。我们假设，远端pO 2将是低的囊性纤维化（CF）airways.Materials和MethodsWe测定的分数呼气氧（FEO 2）在真实的时间使用快速激光二极管分析仪在健康受试者和CF，哮喘和原发性纤毛运动障碍（PCD）的患者。受试者缓慢呼气至剩余容量（RV），记录FEO 2（NFO）的最低值。将数值与外周血氧饱和度（SaO 2）、RV呼气CO2、FEV 1、FEV 1/FVC和FEF 25 - 75进行比较。我们还测量了辅助供氧对FEO 2的影响。结果74例受试者完成了研究。另外7名受试者无法执行该动作。对照组（n= 29）、CF组（n= 23）、哮喘组（n= 15）和PCD组（n= 7）的平均（±SD）NFO值分别为13.4 ± 1.1%、12.4 ± 1.2%、13.3 ± 1.1%、14.4 ± 0.6%。CF组NFO低于对照组（P= 0.0162），PCD组NFO高于CF组（P= 0.0007）。哮喘结果不均匀。氧气导致NFO剂量依赖性增加（P< 0.0005;n= 3;r2= 0.91）。NFO值与FEV 1（P= 0.0009）、FEV 1/FVC（P= 0.0019）和FEF 25 - 75（P= 0.0155）呈正相关，与SaO 2无相关性。这可能反映了部分堵塞的腺泡单位中的氧吸收，和/或增加的上皮氧消耗。远端气道pO 2可精确滴定以治疗感染。
ObjectivesOxygen tension affects the biology of aerobic and denitrifying organisms. Using a novel, fast‐response sensor, we developed a noninvasive procedure to measure pO2in distal human airways. We hypothesized that distal pO2would be low in cystic fibrosis (CF) airways.Materials and MethodsWe measured the fraction of expired oxygen (FEO2) in real time using a fast laser diode analyzer in healthy subjects and in patients with CF, asthma, and primary ciliary dyskinesia (PCD). Subjects slowly exhaled to residual volume (RV), where the nadir of FEO2(NFO) was recorded. Values were compared to peripheral oxygen saturation (SaO2), expired CO2at RV, FEV1, FEV1/FVC, and FEF25‐75. We also measured the effect of supplemental oxygen on FEO2.ResultsSeventy‐four subjects completed the study. Seven additional subjects could not perform the maneuver. Mean (±SD) NFO values for controls (n= 29), CF patients (n= 23), asthma patients (n= 15), and PCD patients (n= 7) were 13.4 ± 1.1%, 12.4 ± 1.2%, 13.3 ± 1.1%, 14.4 ± 0.6%, respectively. NFO in CF was lower than in controls (P= 0.0162), and NFO in PCD was higher than in CF (P= 0.0007). Asthma results were heterogeneous. Oxygen caused a dose‐dependent increase in NFO (P< 0.0005;n= 3;r2= 0.91). NFO values were positively associated with FEV1(P= 0.0009), FEV1/FVC (P= 0.0019) and FEF25‐75(P= 0.0155), but there was no association with SaO2.ConclusionsDistal airway pO2is lower in CF than in controls. This may reflect absorption of oxygen in partially plugged acinar units, and/or increased epithelial oxygen consumption. Distal airway pO2can be precisely titrated to treat infections.