Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning.
Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning.
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视觉辨别和逆转学习需要多巴胺 D2L 受体。
DOI：
10.1159/000447970
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Hikida,Takatoshi
中科院分区：
文献类型：
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作者：
Morita,Makiko;Wang,Yanyan;Sasaoka,Toshikuni;Okada,Kinya;Niwa,Minae;Sawa,Akira;Hikida,Takatoshi
皮质纹状体丘脑回路通过多巴胺神经传递调节学习行为。D2长（D2L）受体是多巴胺D2受体（D2Rs）的同种型，并且可以主要作用于突触后位点。众所周知，D2R影响高级脑功能，但单个D2R亚型的作用仍不清楚。为了评估D2L受体在视觉辨别学习中的影响，我们使用触摸屏操作系统对D2L基因敲除小鼠进行视觉辨别和反转任务。基因型之间在操作性条件反射任务上没有显著差异。然而，D2L基因敲除小鼠在视觉辨别和反向学习任务中均受损。D2L基因敲除小鼠在视觉辨别任务中收集奖励的速度也明显慢于野生型小鼠。这些结果表明，D2L受体在视觉辨别和逆转学习中起重要作用。
The corticostriatothalamic circuit regulates learning behaviors via dopamine neurotransmission. D2 long (D2L) receptors are an isoform of dopamine D2 receptors (D2Rs) and may act mainly at postsynaptic sites. It is well known that D2Rs influence high brain functions, but the roles of individual D2R isoforms are still unclear. To assess the influence of D2L receptors in visual discrimination learning, we performed visual discrimination and reversal tasks with D2L knockout mice using a touchscreen operant system. There were no significant differences in an operant conditioning task between genotypes. However, D2L knockout mice were impaired in both visual discrimination and reversal learning tasks. D2L knockout mice were also significantly slower than wild-type mice in collecting the reward in the visual discrimination task. These results indicate that D2L receptors play an important role in visual discrimination and reversal learning.