A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors
A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors
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DOI：
10.1007/s00421-010-1473-z
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发表时间：
2010-09-01
影响因子：
3
通讯作者：
Higuchi, M.
中科院分区：
文献类型：
--
作者：
Sanada, K.;Miyachi, M.;Higuchi, M.
在这项针对日本男性和女性的研究中，我们确定了骨质疏松症的参考值，并检验了骨质疏松症与心血管疾病危险因素相关的假设，与腰围无关。共有1,488名年龄在18-85岁的日本男性和女性参与了这项研究。用双能X线骨密度仪测定阑尾肌质量(AMM)。男女1级和2级骨质疏松症参考值(骨骼肌指数：AMM/身高(2)，Kgm(-2))被定义为低于本研究从18-40岁青年获得的特定性别参考值平均值的一个和两个标准差。1级和2级石棺减少的参考值男性分别为7.77和6.87 kg m(-2)，女性分别为6.12和5.46 kg m(-2)。在1级和2级石棺减少的受试者中，体重指数和体脂百分比均显著低于正常受试者。采用单因素方差分析，调整腰围协变量后，尽管男性1级骨质疏松症患者的全血糖化血红蛋白A1c显著高于正常对照组，而女性1、2级骨质疏松症患者的臂踝脉搏波速度均显著高于正常对照组。虽然骨质疏松症与瘦体重有关，但它与男性更多的血清蛋白糖化和女性更大的动脉僵硬有关，与腰围无关。
In this study of Japanese men and women, we determine reference values for sarcopenia and test the hypothesis that sarcopenia is associated with risk factors for cardiovascular disease, independent of waist circumference. A total of 1,488 Japanese men and women aged 18-85 years participated in this study. Appendicular muscle mass (AMM) was measured by dual-energy X-ray absorptiometry. Reference values for classes 1 and 2 sarcopenia (skeletal muscle index: AMM/height(2), kg m(-2)) in each sex were defined as values one and two standard deviations below the sex-specific means of reference values obtained in this study from young adults aged 18-40 years. The reference values for class 1 and class 2 sarcopenia were 7.77 and 6.87 kg m(-2) in men and 6.12 and 5.46 kg m(-2) in women. In subjects both with class 1 and class 2 sarcopenia, body mass index and % body fat were significantly lower than in normal subjects. Despite whole-blood glycohaemoglobin A1c in men with class 1 sarcopenia was significantly higher than in normal subjects, and brachial-ankle pulse wave velocity in women both with class 1 and class 2 sarcopenia were significantly higher than in normal subjects, using one-way ANCOVA with adjustment for the covariate of waist circumference. Although sarcopenia is associated with thin body mass, it is associated with more glycation of serum proteins in men and with greater arterial stiffness in women, independent of waist circumference.