Ancient goat genomes reveal mosaic domestication in the Fertile Crescent
Ancient goat genomes reveal mosaic domestication in the Fertile Crescent
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DOI：
10.1126/science.aas9411
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发表时间：
2018-07-06
期刊：
影响因子：
56.9
通讯作者：
Bradley, Daniel G.
中科院分区：
文献类型：
--
作者：
Daly, Kevin G.;Delser, Pierpaolo Maisano;Bradley, Daniel G.
目前的遗传数据是模棱两可的山羊驯化是否发生多次或一个单一的过程。我们从整个近东地区从旧石器时代到中世纪的83只古山羊（51只全基因组覆盖）中产生了基因组数据。我们的研究结果表明，多个不同的古代野生山羊来源是在一个分散的过程中驯化的，这导致了基因和地理上不同的新石器时代山羊种群，这与该地区同期人类的分歧相呼应。这些早期的山羊种群对亚洲、非洲和欧洲的现代山羊做出了不同的贡献。我们还发现了色素沉着，身高，繁殖，挤奶和对饮食变化的反应的早期选择，为人类在伙伴物种中塑造基因组变异提供了8000年的证据。
Current genetic data are equivocal as to whether goat domestication occurred multiple times or was a singular process. We generated genomic data from 83 ancient goats (51 with genome-wide coverage) from Paleolithic to Medieval contexts throughout the Near East. Our findings demonstrate that multiple divergent ancient wild goat sources were domesticated in a dispersed process that resulted in genetically and geographically distinct Neolithic goat populations, echoing contemporaneous human divergence across the region. These early goat populations contributed differently to modern goats in Asia, Africa, and Europe. We also detect early selection for pigmentation, stature, reproduction, milking, and response to dietary change, providing 8000-year-old evidence for human agency in molding genome variation within a partner species.