Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men.
Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men.
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DOI：
10.2337/dc13-0800
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发表时间：
2013-11
期刊：
影响因子：
16.2
通讯作者：
Laakso M
中科院分区：
文献类型：
--
作者：
Mahendran Y;Cederberg H;Vangipurapu J;Kangas AJ;Soininen P;Kuusisto J;Uusitupa M;Ala-Korpela M;Laakso M
我们调查了空腹血清甘油和脂肪酸(FAs)作为高血糖恶化和2型糖尿病发生的预测因子之间的关系。基于人群的男性代谢综合征(METSIM)研究的横断面和纵向分析包括9,398名芬兰男性(平均年龄57±7岁)。在基线时，用质子核磁共振波谱测量血清甘油、游离脂肪酸(FFAs)水平和血清FA相对总FAs的比例。在空腹和2小时高血糖组中，甘油、游离脂肪酸、单不饱和脂肪酸、饱和脂肪酸、单不饱和脂肪酸、n-7和-9脂肪酸水平相对于总脂肪酸水平升高，而n-3和n-6脂肪酸水平相对于总脂肪酸水平降低(N=9,398)。在4335名有4.5年随访数据的男性中，276人患上了2型糖尿病。甘油、游离脂肪酸、单不饱和脂肪酸、饱和和单不饱和脂肪酸水平相对于总脂肪酸水平的升高预测了高血糖的恶化和在调整混杂因素后发生的2型糖尿病。相对于总脂肪酸，N-6脂肪酸，主要是亚油酸(LA)，与降低高血糖恶化和转化为2型糖尿病的风险相关。我们的大型人群研究表明，空腹血清甘油、游离脂肪酸、单不饱和脂肪酸、饱和脂肪酸、n-7和-9脂肪酸水平是患高血糖和2型糖尿病风险增加的生物标志物，而反映膳食LA摄入量的高血清n-6脂肪酸水平与高血糖和2型糖尿病风险降低相关。
We investigated the association of fasting serum glycerol and fatty acids (FAs) as predictors for worsening of hyperglycemia and incident type 2 diabetes. Cross-sectional and longitudinal analyses of the population-based METabolic Syndrome in Men (METSIM) Study included 9,398 Finnish men (mean age 57 ± 7 years). At baseline, levels of serum glycerol, free FAs (FFAs), and serum FA profile, relative to total FAs, were measured with proton nuclear magnetic resonance spectroscopy. At baseline, levels of glycerol, FFAs, monounsaturated FAs, saturated FAs, and monounsaturated n-7 and -9 FAs, relative to total FAs, were increased in categories of fasting and 2-h hyperglycemia, whereas the levels of n-3 and n-6 FAs, relative to total FAs, decreased (N = 9,398). Among 4,335 men with 4.5-year follow-up data available, 276 developed type 2 diabetes. Elevated levels of glycerol, FFAs, monounsaturated FAs, and saturated and monounsaturated n-7 and -9 FAs, relative to total FAs, predicted worsening of hyperglycemia and development of incident type 2 diabetes after adjustment for confounding factors. n-6 FAs, mainly linoleic acid (LA), relative to total FAs, were associated with reduced risk for the worsening of hyperglycemia and conversion to type 2 diabetes. Our large population-based study shows that fasting serum levels of glycerol, FFAs, monounsaturated FAs, saturated FAs, and n-7 and -9 FAs are biomarkers for an increased risk of development of hyperglycemia and type 2 diabetes, whereas high levels of serum n-6 FAs, reflecting dietary intake of LA, were associated with reduced risk for hyperglycemia and type 2 diabetes.