High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis
High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis
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DOI：
10.1128/aac.03705-14
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Altare, Frederic
中科院分区：
文献类型：
--
作者：
Silva-Miranda, Mayra;Ekaza, Euloge;Altare, Frederic
Tuberculosis remains a major health problem due to the emergence of drug-resistant strains of Mycobacterium tuberculosis. Some models have provided valuable information about drug resistance and efficacy; however, the translation of these results into effective human treatments has mostly proven unsuccessful. In this study, we adapted high-content screening (HCS) technology to investigate the activities of antitubercular compounds in the context of an in vitro granuloma model. We observed significant shifts in the MIC(50)s between the activities of the compounds under extracellular and granuloma conditions.
