Pineocytoma and Pineal Parenchymal Tumors of Intermediate Differentiation Presenting Cytologic Pleomorphism: A Multicenter Study
Pineocytoma and Pineal Parenchymal Tumors of Intermediate Differentiation Presenting Cytologic Pleomorphism: A Multicenter Study
复制标题
松果体细胞瘤和中间分化的松果体实质肿瘤呈现细胞学多形性：一项多中心研究
DOI：
10.1111/j.1750-3639.2008.00128.x
复制
发表时间：
2008
期刊：
影响因子：
6.4
通讯作者：
A. Jouvet
中科院分区：
文献类型：
--
作者：
M. Fèvre;A. Szathmari;J. Champier;K. Mokhtari;F. Chrétien;A. Coulon;D. Figarella;M. Polivka;P. Varlet;E. Uro;F. Fauchon;A. Jouvet
在有限数量的良性松果体肿瘤中描述了细胞学多形性，即松果体细胞瘤（PC）和中间分化的松果体实质肿瘤（PPTID）。我们检查了 14 例（7 名女性和 7 名男性，年龄在 10 至 65 岁之间）多形性 PPT 病例的回顾性系列临床病理特征。 7例为PC，无核分裂象，肿瘤细胞区域形成大的松果体玫瑰花结，其他区域有含有深染细胞核的巨细胞。另外7个是PPTID，有丝分裂很少（≤2），Ki67增殖指数在3%到7%之间，主要由小肿瘤细胞和分散的巨细胞组成，有时是多核的。在14个肿瘤中，多形性区域的比例是可变的。大多数肿瘤细胞表现出广泛的神经元分化，并强烈表达神经元特异性烯醇化酶、突触素和神经丝。一些肿瘤细胞表达S100蛋白。随访时间为 1.2 至 13 年，仅 1 例 PC 和 1 例 PPTID 在立体定向活检或不完全切除后出现进展。尽管这些肿瘤具有明显的多形性，但缺乏侵袭性和低增殖指数表明其临床病程为良性，后者可能导致升级。
Cytologic pleomorphism has been described in a limited number of benign pineal tumors, namely pineocytoma (PC) and pineal parenchymal tumors (PPTs) of intermediate differentiation (PPTID). We examined the clinicopathologic features in a retrospective series of 14 cases (seven females and seven males aged from 10 to 65 years) of pleomorphic PPT. Seven cases were PC, with no mitoses and with areas of tumoral cells forming large pineocytomatous rosettes and other areas with giant cells containing hyperchromatic nuclei. The other seven were PPTID, presenting few mitoses (≤2), a Ki67 proliferation index between 3% and 7%, and predominantly composed of small neoplastic cells and scattered giant cells, sometimes multinucleated. In the 14 tumors, the proportion of pleomorphic areas was variable. Most tumoral cells showed extensive neuronal differentiation with strong expression of neuron‐specific enolase, synaptophysin and neurofilaments. Some of the neoplastic cells expressed S100 protein. The follow‐up period ranged from 1.2 to 13 years and only one PC and one PPTID progressed after stereotactic biopsy or incomplete resection. The lack of invasiveness and the low proliferation index of these tumors suggest a benign clinical course despite the marked pleomorphism, the latter of which can lead to upgrading.