Risk factors for breast cancer in a black population-The Barbados National Cancer Study
Risk factors for breast cancer in a black population-The Barbados National Cancer Study
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DOI：
10.1002/ijc.23827
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发表时间：
2009-01-01
影响因子：
6.4
通讯作者：
Hennis, Anselm J.
中科院分区：
文献类型：
--
作者：
Nemesure, Barbara;Wu, Suh-Yuh;Hennis, Anselm J.
巴巴多斯国家癌症研究（BNCS）是一项全国性的病例对照研究，旨在调查与非洲裔美国人具有相似血统的主要非洲裔人群中乳腺癌（BC）的环境和遗传因素。本报告评估了BNCS中BC事件与各种因素的关联，包括人口统计学，人体测量学，生殖和家族史变量，以前未在该人群中进行过调查。英国国家统计局包括241例BC事件和481例。年龄匹配的女性对照，平均年龄分别为57岁和56岁。除了近亲中报告的BC家族史[父母中的比值比（OR）= 3.74，95%CI（1.41，9.90）;兄弟姐妹中的OR = 3.26（1.47，7.21）]外，与BC相关的其他因素是首次足月妊娠时年龄较大[OR = 1.47，7.21]。有乳腺良性疾病史[OR = 1.88（1.19，2.99）]。产次增加降低了BC的风险[在>= 3个孩子的人群中OR = 0.34（0.15，0.77）]。非洲-巴巴多斯（AB）妇女的生殖模式往往不同于非洲-美国（AA）妇女（初潮年龄晚，首次怀孕年龄早，哺乳频率高，不经常使用外源性激素），并有助于解释其绝经后BC发病率相当低。报告的家族史和BC之间的关系，再加上协会指出的几个生殖和其他变量，支持遗传和环境的贡献，BC，这可能会有所不同，在整个非洲散居人口。对其他人群的进一步调查可能会澄清这些问题。(C)2008 Wiley-Liss，Inc.
The Barbados National Cancer Study (BNCS) is a nationwide case-control study investigating environmental and genetic factors for breast cancer (BC) in a predominantly African-origin population with similar ancestry as African-Americans. This report evaluates associations of incident BC in the BNCS to various factors, including demographic, anthropometric, reproductive and family history variables, not investigated previously in this population. The BNCS included 241 incident BC cases and 481. age-matched female controls, with mean ages of 57 and 56 years, respectively. In addition to a reported family history of BC in a close relative [odds ratios (OR) = 3.74, 95% CI (1.41, 9.90) in a parent; OR = 3.26 (1.47, 7.21) in a sibling], other factors associated with BC were older age at first full-term pregnancy [OR = 1..04 (1.00, 1.07)] and having a history of benign breast disease [OR = 1.88 (1.19, 2.99)]. Increased parity reduced the risk of BC [OR = 0.34 (0.15, 0.77) among those with >= 3 children]. The reproductive patterns of African-Barbadian (AB) women tended to differ from those of African-American (AA) women (later age of menarche, earlier age at first pregnancy, higher frequency of lactation and infrequent use of exogenous hormones) and could help to explain their considerably lower postmenopausal incidence of BC. The relationship between reported family history and BC, combined with the associations noted for several reproductive and other variables, supports the genetic and environmental contributions to BC, which may vary in populations across the African diaspora. Further investigations of other populations may clarify these issues. (C) 2008 Wiley-Liss, Inc.