Precancerous gastric lesions in a population at high risk of stomach cancer.
Precancerous gastric lesions in a population at high risk of stomach cancer.
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发表时间：
1993-03
期刊：
影响因子：
11.2
通讯作者：
W. You;W. Blot;Ji-you Li;Yun‐sheng Chang;M. Jin;R. Kneller;Lian Zhang;Zhongxiang Han;Xiang-rui Zeng;Wei‐dong Liu;Lei Zhao;P. Correa;J. Fraumeni;Guang‐wei Xu
中科院分区：
文献类型：
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作者：
W. You;W. Blot;Ji-you Li;Yun‐sheng Chang;M. Jin;R. Kneller;Lian Zhang;Zhongxiang Han;Xiang-rui Zeng;Wei‐dong Liu;Lei Zhao;P. Correa;J. Fraumeni;Guang‐wei Xu
一项基于人群的早期癌症筛查评估了中国山东省一个地区的胃癌前病变患病率，该地区是世界上胃癌发病率最高的地区之一。共有3433名年龄在35岁至64岁之间的居民接受了胃镜检查，并从标准位置进行了活检。慢性萎缩性胃炎几乎是普遍的，只有不到2%的人群活检显示粘膜完全正常或仅为浅表性胃炎。肠上皮化生是最晚期的病变，占33%，胃异型增生占20%，尽管每种病变的患病率随年龄的增长而显著增加。在整个胃中检测到肠上皮化生和胃发育不良，但病变沿着胃小弯更明显，尤其是在胃角和胃窦。慢性萎缩性胃炎的发病率没有性别差异，但男性肠上皮化生的患病率略高，异型增生增加1.6倍，胃癌增加3倍。这些数据量化了在这一高危人群中胃癌自然史中可能涉及的胃部病变的广泛性。
A population-based screening for detection of early cancers evaluated the prevalence of precancerous gastric lesions in an area in Shandong province, China, with one of the world's highest rates of stomach cancer. A total of 3433 residents aged 35 to 64 yr received gastroscopical examinations with biopsies taken from standard locations. Chronic atrophic gastritis was nearly universal; less than 2% of the population had biopsies showing entirely normal mucosa or only superficial gastritis. Intestinal metaplasia was the most advanced lesion for 33% and gastric dysplasia for 20%, although the prevalence of each increased significantly with age. Intestinal metaplasia and gastric dysplasia were detected throughout the stomach, but the lesions were more pronounced along the lesser curvature, especially in the angulus and antrum. There was no sex difference in rates of chronic atrophic gastritis, but males had a slightly higher prevalence of intestinal metaplasia, a 1.6-fold increase in dysplasia, and a 3-fold excess of gastric cancer. The data quantify the extensiveness of gastric lesions likely to be involved in the natural history of stomach cancer in this high-risk population.