Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma
Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma
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DOI：
10.1097/00001813-199804000-00008
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发表时间：
1998-04-01
影响因子：
2.3
通讯作者：
Hosokawa, M
中科院分区：
文献类型：
--
作者：
Matsushita, K;Kuramitsu, Y;Hosokawa, M
本文观察了香菇活性己糖相关化合物（AHCC）对UFT治疗先天性T细胞抑制型自发性高血压大鼠（SHR）乳腺癌SST-2细胞的协同作用。AHCC加UFT对原发肿瘤的生长有轻微但显著的影响。AHCC加UFT对肺转移无明显抑制作用，但对腋窝淋巴结转移有明显抑制作用。AHCC + UFT联合治疗原发性肿瘤切除后出现加速肺转移的SHR大鼠，显示出相似的协同抗转移作用。体外研究表明，AHCC加UFT增强荷瘤大鼠NK细胞活性，而UFT单独抑制NK细胞活性。AHCC + UFT还能增强腹腔巨噬细胞的NO生成和细胞毒性。此外，AHCC恢复了化疗诱导的白细胞介素-1 α和肿瘤坏死因子-α的抑制mRNA表达。总之，AHCC + UFT的组合不仅对原发肿瘤生长而且对减少转移带来良好的治疗效果，并且这些效果是由AHCC恢复或激活的宿主免疫介导的。AHCC可能是生物反应调节剂的良好候选者。[(C)1998 Lippincott-Raven Publishers.
Synergistic effects of active hexose correlated compound (AHCC) extracted from mushroom on the treatment with UFT against mammary adenocarcinoma, SST-2 cells, in congenitally T cell-depressed spontaneously hypertensive rats (SHR) were observed. AHCC plus UFT had slight but significant effects on the growth of primary tumors. Pulmonary metastases were not inhibited by the treatment with AHCC plus UFT, whereas metastases to axillay lymph nodes (LN) were obviously inhibited. Combination of AHCC plus UFT showed similar synergistic anti-metastatic effects in SHR rats with accelerated pulmonary metastases following the surgical removal of the primary tumors. In vitro studies demonstrated that AHCC plus UFT enhanced the NK cell activity in tumor-bearing rats, whereas UFT alone depressed the NK cell activity. AHCC plus UFT also enhanced the NO production and cytotoxicity of peritoneal macrophages. In addition, AHCC restored the suppressed mRNA expression of interleukin-1 alpha and tumor necrosis factor-alpha induced by the chemotherapy. Taken together, the combination of AHCC plus UFT brought about good therapeutic effects not only on primary tumor growth but also on reducing metastasis and these effects were mediated by host immunity which was restored or activated by AHCC. AHCC may be a good candidate for a biological response modifier. [(C) 1998 Lippincott-Raven Publishers.].