LYMPHOCYTE-T SUBSETS DURING PREGNANCY AND THE MENSTRUAL-CYCLE
LYMPHOCYTE-T SUBSETS DURING PREGNANCY AND THE MENSTRUAL-CYCLE
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DOI：
10.1111/j.1600-0897.1983.tb00259.x
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
FATHMAN, CG
中科院分区：
文献类型：
--
作者：
COULAM, CB;SILVERFIELD, JC;FATHMAN, CG
许多观察表明，细胞免疫功能在妊娠期受到抑制。为了确定怀孕期间循环淋巴细胞亚群的变化，我们比较了31名处于妊娠不同阶段的孕妇外周血中总T细胞、T辅助细胞和T抑制细胞的百分比与未怀孕对照组的百分比。对照研究包括5名服用口服避孕药的妇女和5名自行月经的妇女。将分离的外周血单核细胞与Leu‐2细胞、Leu‐3细胞和Leu‐4细胞特异性的荧光单克隆抗体反应，随后在荧光激活的细胞分选器上进行分析。在月经周期或口服避孕药周期中，未观察到Leu‐2、Leu‐3或Leu‐4细胞百分比的变化。当将妊娠不同阶段的T细胞亚群与未妊娠对照的相应T细胞亚群进行比较时，没有发现差异。数据表明，妊娠不会改变外周血中T细胞亚群的百分比。
Many observations suggest that cellular immunity is depressed during gestation. To define alterations in subsets of circulating lymphocytes during pregnancy, we compared the percentages of total T cells, T helper cells, and T suppressor cells in the peripheral blood of 31 pregnant women at various stages of gestation with those in that of nonpregnant controls. Control studies consisted of five women ingesting oral contraceptives and five women menstruating spontaneously. Isolated peripheral blood mononuclear cells were reacted with fluoresceinated monoclonal antibodies that were specific for Leu‐2 cells, Leu‐3 cells, and Leu‐4 cells and that were subsequently analyzed on a fluorescence‐activated cell sorter. No variation in the percentage of Leu‐2, Leu‐3, or Leu‐4 cells was observed during the menstrual cycle or oral contraceptive cycle. No differences were seen when T‐cell subsets at various stages of gestation were compared with the corresponding T‐cell subset in nonpregnant controls. The data suggest that pregnancy does not alter the percentage of T‐cell subsets in the peripheral blood.