Factors associated with cortical and trabecular bone loss as quantified by peripheral computed tomography (pQCT) at the ultradistal radius in aging women
Factors associated with cortical and trabecular bone loss as quantified by peripheral computed tomography (pQCT) at the ultradistal radius in aging women
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DOI：
10.1007/s002239900208
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发表时间：
1997-02-01
影响因子：
4.2
通讯作者：
Aerssens, J
中科院分区：
文献类型：
--
作者：
Boonen, S;Cheng, XG;Aerssens, J
外周定量计算机断层扫描（pQCT）可以单独确定外周骨骼中的皮质骨和小梁骨矿物质密度。这项横断面研究旨在检查健康老龄化对桡骨超远端pQCT测量的影响。在129名年龄在70-87岁的社区妇女的明确样本中，年龄范围内皮质和骨小梁密度的差异分别相当于每年损失-0.41%和-0.65%。为了研究这种年龄相关性下降的机制，我们评估了两个参数与身高、体重、体重指数、膳食钙摄入量、握力和胰岛素样生长因子-I（IGF-I）、骨化二醇（25（OH）D-3）、骨化三醇（1，25（OH）（2）D-3）、甲状旁腺激素（PTH）和性激素结合球蛋白（SHBG）血清浓度之间的关系。使用多元回归校正潜在混杂因素。在控制了其他协变量后，年龄并不显著。体重指数、握力、血清IGF-I、25（OH）D-3和PTH（1-84）是总骨密度的独立预测因子。包括（总的或游离的）1，25（OH）（2）D-3并没有提高模型的精度。这些发现提供的证据表明，除其他因素外，生长激素-IGF-I-轴的活性对骨骼完整性具有重要意义。握力、血清IGF-I和PTH（1-84）与皮质骨密度显著相关，但与骨小梁密度无关，表明致密骨和松质骨丢失可能涉及不同的机制。
Peripheral quantitative computed tomography (pQCT) allows the separate determination of cortical and trabecular bone mineral density in the peripheral skeleton. This cross-sectional study was designed to examine the effects of healthy aging on pQCT measurements at the ultradistal radius. In a well-defined sample of 129 community-based women, aged 70-87 years, the differences in cortical and trabecular density over the age range were equivalent to losses of -0.41% and -0.65% per year, respectively. To investigate the mechanism of this age-related decline, we assessed relationships between both parameters and height, weight, body mass index, dietary calcium intake, grip strength, and serum concentrations of insulin-like growth factor-I (IGF-I), calcidiol (25(OH)D-3), calcitriol (1,25(OH)(2)D-3), parathyroid hormone (PTH), and sex hormone binding globulin (SHBG). Multiple regression was used to adjust for potential confounders. Age was not significant after controlling for other covariables. Body mass index, grip strength, serum IGF-I, 25(OH)D-3, and PTH (1-84) were found to be independent predictors of total bone density. Including (total or free) 1,25(OH)(2)D-3 did not improve the model precision. These findings provide evidence that, among other factors, the activity of the growth hormone-IGF-I-axis is of importance for skeletal integrity. Grip strength, serum IGF-I, and PTH (1-84) were discovered to be significantly related to cortical but not to trabecular density, suggesting that different mechanisms may be involved in compact and cancellous bone loss.